Gastrointestinal motility disorder assessment in systemic sclerosis

Edoardo Savarino, Federico Mei, Andrea Parodi, Massimo Ghio, Manuele Furnari, Adelina Gentile, Michela Berdini, Antonio Di Sario, Emanuele Bendia, Patrizia Bonazzi, Emidio Scarpellini, Lucrezia Laterza, Vincenzo Savarino, Antonio Gasbarrini

Research output: Contribution to journalArticlepeer-review


Objectives: SSc is a clinically heterogeneous and generalized disease, characterized by thickness of the connective tissue of the skin and internal organs, such as the digestive tract, impairing gastrointestinal (GI) motility. Our aim is to evaluate retrospectively abnormalities of oesophageal motility, gastric emptying, oro-cecal transit time (OCTT) and small intestine bacterial overgrowth (SIBO) in a large cohort of SSc patients. Methods: Ninety-nine SSc patients were included in the study. Forty-two patients underwent oesophageal conventional manometry, 45 performed a [13C]octanoic acid breath test to measure gastric emptying time and all 99 patients performed a lactulose breath test in order to evaluate OCTT and SIBO. Data were compared with healthy controls. Results: In SSc patients, median lower oesophageal sphincter (LOS) pressure [14mmHg (25th-75th; 8-19) vs 24mmHg (19-28); P1/2 was 141 ± 79 min vs 90 ± 40 min of controls (P

Original languageEnglish
Pages (from-to)1095-1100
Number of pages6
Issue number6
Publication statusPublished - Jun 2013


  • C-octanoate breath test
  • Gastrointestinal motility
  • Lactulose breath test
  • Oesophageal manometry
  • Scleroderma
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)


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