Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (Type 2) diabetes mellitus

Vito Annese, Gabrio Bassotti, Nazario Caruso, Salvatore De Cosmo, Armando Gabbrielli, Sergio Modoni, Vincenzo Frusciante, Angelo Andriulli

Research output: Contribution to journalArticle

Abstract

Although relatively frequent, diabetic involvement of digestive tract motility has not been investigated extensively in different organs. The authors studied esophageal, gastric, and gallbladder motor function in 35 type 2 (noninsulin-dependent) diabetic patients to determine the extent of gut involvement. Of these patients, 27 (77%) had peripheral neuropathy, 12 (34%) had both peripheral and autonomic neuropathy, and 22 (63%) had gastrointestinal symptoms. Esophageal manometric abnormalities were recorded in 18 patients, and delayed radionuclide emptying of the esophagus was documented in 16 patients, with a 83% concordance between the two tests. Scintigraphic gastric emptying of solids was delayed in 56% of patients, whereas gallbladder emptying after cholecystokinin stimulation was reduced in 69% of them. In 74% of patients at least one of the viscera under investigation showed abnormal motor function; however, only 36% of patients displayed involvement of the three organs. Gastrointestinal symptoms, duration and therapy of diabetes, previous poor glycemic control, and retinopathy did not correlate with the presence or the extent of motor disorders. Neuropathy was not predictive of gastrointestinal involvement and its extent; however, when motor abnormalities were present in patients with neuropathy, these were usually more severe. Gastrointestinal motor disorders are frequent and widespread in type 2 diabetics, regardless of symptoms. Autonomic neuropathy has a poor predictive value on motor disorders (0.75 for the esophagus, 0.5 for the stomach, 0.8 for the gallbladder), thus suggesting the coexistence of other pathophysiologic mechanisms.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalJournal of Clinical Gastroenterology
Volume29
Issue number2
DOIs
Publication statusPublished - Sep 1999

Fingerprint

Type 2 Diabetes Mellitus
Peripheral Nervous System Diseases
Gallbladder
Esophagus
Stomach
Gallbladder Emptying
Viscera
Gastric Emptying
Cholecystokinin
Radioisotopes
Gastrointestinal Tract
Motor Disorders

Keywords

  • Diabetes
  • Dysmotilities
  • Manometry
  • Scintigraphy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (Type 2) diabetes mellitus. / Annese, Vito; Bassotti, Gabrio; Caruso, Nazario; De Cosmo, Salvatore; Gabbrielli, Armando; Modoni, Sergio; Frusciante, Vincenzo; Andriulli, Angelo.

In: Journal of Clinical Gastroenterology, Vol. 29, No. 2, 09.1999, p. 171-177.

Research output: Contribution to journalArticle

Annese, Vito ; Bassotti, Gabrio ; Caruso, Nazario ; De Cosmo, Salvatore ; Gabbrielli, Armando ; Modoni, Sergio ; Frusciante, Vincenzo ; Andriulli, Angelo. / Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (Type 2) diabetes mellitus. In: Journal of Clinical Gastroenterology. 1999 ; Vol. 29, No. 2. pp. 171-177.
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