Gastrointestinal polyposis and skin disease: Report of two cases

C. Alvisi

Research output: Contribution to journalArticlepeer-review

Abstract

Gastrointestinal polyposis syndromes are characterized by the development of hundreds of polyps especially in the colon. In some cases they are accompanied by extraintestinal manifestation that in few cases can also be cutaneous lesions. These can be very important markers that can help to identify patients who suffer from polyposis syndrome that are at high risk to evolve into colorectal cancer. For this reason patients must be screened in order to find and to remove polyps that are premalignant lesions. American gastroentcrological association screening and surveillance guideline suggest that for suspected polyposis syndrome patient and all his relatives must have genetical screening and analysis and if mutation is found colonoscopy must be performed every year from adolescence to look for and to remove polyps. It is also considered the best time to have colectomy. We observed two cases of polyposis syndrome and both underwent surgical therapy. Only the first case had cutaneous lesions. Gastrointestinal polyposis are rare and for this reason they are sometimes not acknowledged. So it's important to perform careful physical examination to find markers of the disease but from gastroenterological point of view the absence of extraintestinal manifestation must no underestimate poor gastrointestinal symptoms. So it's important to perform screening and surveillance when gastrointestinal diseases are found but it must be observed that for a good program strategy it's important to ensure that patients are fully informed about screening even if it's non known which educational intervention are more effective in raising public, patient and clinical awareness of the magnitude of the risk of colorectal cancer.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalInternational Journal of Medicine, Biology and the Environment
Volume27
Issue number1
Publication statusPublished - 1999

Keywords

  • Cowden's Syndrome
  • Cronkhite-Canada Syndrome
  • Gardner's Syndrome
  • Gastrointestinal polyposis
  • Peutz-Jegher's Syndrome
  • Skin diseases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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