Gastrointestinal stromal tumor, uncommitted type, with monosomies 14 and 22 as the only chromosomal abnormalities

Valerio Marci, Laura Casorzo, Ivana Sarotto, Natalia Dogliani, Maria Giovanna Milazzo, Mauro Risio

Research output: Contribution to journalArticle

Abstract

Karyotypic analysis of a gastric stromal tumor with the histologic and immunohistochemical features of a malignant, uncommitted lesion revealed clonal monosomies of chromosomes 14 and 22. Such changes, together with loss of chromosomes 15 and 18, as well as structural rearrangements involving chromosome 1, have been previously reported in gastrointestinal stromal tumors with smooth muscle differentiation. We suggest that monosomies of chromosomes 14 and 22 are early events in the malignant transformation of the mesenchymal cell-originating gastrointestinal stromal tumors.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume102
Issue number2
DOIs
Publication statusPublished - Apr 1998

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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