Abstract
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the alimentary tract. They normally involve the stomach, the small bowel, or the colon. Localisation within the oesophagus, rectum, mesentery, omentum, or retroperitoneum is less common. GISTs are immunohistochemically identified by the expression of the c-kit protein, which is not detected in other mesenchymal tumours. The role of imaging includes the detection (subjects with occult gastrointestinal bleeding, incidental recognition, etc.), characterisation, analysis of relations between mass and gastrointestinal wall, staging, prognostic assessment (recognition of signs of malignancy and unfavourable prognosis), and follow-up during specific treatment. Owing to the frequent exophytic growth of these lesions, differentiation of these tumours from nondigestive lesions of different nature is a common diagnostic problem. Imaging findings usually allow differentiation from gastrointestinal epithelial tumours but not from non-epithelial tumours, for which histological confirmation is necessary, in part to verify potential response to therapy. Smaller lesions, which are usually benign, tend to be well-defined, relatively homogeneous, and with intraluminal growth. Larger lesions normally show well-defined or ill-defined margins, inhomogeneous density both on unenhanced and on contrast-enhanced scans, with combined intraluminal/extraluminal growth and a tendency to spread to surrounding structures. Internal attenuation is often necrotic or clearly fluid. Signs of high-grade GIST include liver metastasis, gastrointestinal wall infiltration, large volume, irregular surface, ill-defined margins, inhomogeneous enhancement and peritoneal spread. Recurrences usually share the appearance of the larger, primary malignant GIST.
| Original language | Italian |
|---|---|
| Pages (from-to) | 484-491 |
| Number of pages | 8 |
| Journal | Radiologia Medica |
| Volume | 110 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - Nov 2005 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
I tumori stromali gastrointestinali : Pictorial review. / Catalano, Orlando; De Lutio Di Castelguidone, Elisabetta; Nunziata, Antonio; De Rosa, Vincenzo; Siani, Alfredo.
In: Radiologia Medica, Vol. 110, No. 5-6, 11.2005, p. 484-491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - I tumori stromali gastrointestinali
T2 - Pictorial review
AU - Catalano, Orlando
AU - De Lutio Di Castelguidone, Elisabetta
AU - Nunziata, Antonio
AU - De Rosa, Vincenzo
AU - Siani, Alfredo
PY - 2005/11
Y1 - 2005/11
N2 - Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the alimentary tract. They normally involve the stomach, the small bowel, or the colon. Localisation within the oesophagus, rectum, mesentery, omentum, or retroperitoneum is less common. GISTs are immunohistochemically identified by the expression of the c-kit protein, which is not detected in other mesenchymal tumours. The role of imaging includes the detection (subjects with occult gastrointestinal bleeding, incidental recognition, etc.), characterisation, analysis of relations between mass and gastrointestinal wall, staging, prognostic assessment (recognition of signs of malignancy and unfavourable prognosis), and follow-up during specific treatment. Owing to the frequent exophytic growth of these lesions, differentiation of these tumours from nondigestive lesions of different nature is a common diagnostic problem. Imaging findings usually allow differentiation from gastrointestinal epithelial tumours but not from non-epithelial tumours, for which histological confirmation is necessary, in part to verify potential response to therapy. Smaller lesions, which are usually benign, tend to be well-defined, relatively homogeneous, and with intraluminal growth. Larger lesions normally show well-defined or ill-defined margins, inhomogeneous density both on unenhanced and on contrast-enhanced scans, with combined intraluminal/extraluminal growth and a tendency to spread to surrounding structures. Internal attenuation is often necrotic or clearly fluid. Signs of high-grade GIST include liver metastasis, gastrointestinal wall infiltration, large volume, irregular surface, ill-defined margins, inhomogeneous enhancement and peritoneal spread. Recurrences usually share the appearance of the larger, primary malignant GIST.
AB - Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the alimentary tract. They normally involve the stomach, the small bowel, or the colon. Localisation within the oesophagus, rectum, mesentery, omentum, or retroperitoneum is less common. GISTs are immunohistochemically identified by the expression of the c-kit protein, which is not detected in other mesenchymal tumours. The role of imaging includes the detection (subjects with occult gastrointestinal bleeding, incidental recognition, etc.), characterisation, analysis of relations between mass and gastrointestinal wall, staging, prognostic assessment (recognition of signs of malignancy and unfavourable prognosis), and follow-up during specific treatment. Owing to the frequent exophytic growth of these lesions, differentiation of these tumours from nondigestive lesions of different nature is a common diagnostic problem. Imaging findings usually allow differentiation from gastrointestinal epithelial tumours but not from non-epithelial tumours, for which histological confirmation is necessary, in part to verify potential response to therapy. Smaller lesions, which are usually benign, tend to be well-defined, relatively homogeneous, and with intraluminal growth. Larger lesions normally show well-defined or ill-defined margins, inhomogeneous density both on unenhanced and on contrast-enhanced scans, with combined intraluminal/extraluminal growth and a tendency to spread to surrounding structures. Internal attenuation is often necrotic or clearly fluid. Signs of high-grade GIST include liver metastasis, gastrointestinal wall infiltration, large volume, irregular surface, ill-defined margins, inhomogeneous enhancement and peritoneal spread. Recurrences usually share the appearance of the larger, primary malignant GIST.
KW - Diagnostic imaging
KW - Gastrointestinal stromal tumours
KW - Gastrointestinal tract
UR - http://www.scopus.com/inward/record.url?scp=33644893091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644893091&partnerID=8YFLogxK
U2 - 10.1097/01.rct.0000166635.54240.0d
DO - 10.1097/01.rct.0000166635.54240.0d
M3 - Articolo
C2 - 16437034
AN - SCOPUS:33644893091
VL - 110
SP - 484
EP - 491
JO - Radiologia Medica
JF - Radiologia Medica
SN - 0033-8362
IS - 5-6
ER -