Gastrointestinal telangiectasia

A study by EGD, colonoscopy, and capsule endoscopy in 75 patients

Lino Polese, R. D'Incà, I. Angriman, M. Scarpa, D. Pagano, C. Ruffolo, F. Lamboglia, G. C. Stumiolo, D. F. D'Amico, L. Norberto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The distribution of lesions in the gastrointestinal tract in patients with sporadic telangiectasia is at present unknown. Patients and methods: 75 patients with sporadic telangiectasia underwent esophagogastroduodenoscopy (EGD), capsule endoscopy, and colonoscopy. Endoscopic diagnosis of telangiectasia and gastrointestinal bleeding were required for enrollment in the study. Hemorrhagic diathesis, co-morbidity, number of blood transfusions, and subsequent management were also noted. Results: 35 of the patients presented with gastroduodenal vascular lesions, 51 with small-bowel lesions, and 28 with colonic lesions. 67 % of patients in whom EGD found telangiectasia also presented small-bowel vascular lesions at capsule endoscopy and 43 % colonic lesions at colonoscopy. 54% percent of patients with positive colonoscopy also presented gastroduodenal lesions and 48% small-bowel lesions. Patients with known duodenal lesions were more likely to have small-bowel lesions at capsule endoscopy (odds ratio [OR] 10.19, 95% CI 2.1-49.33, P = 0.003). Patients with associated diseases, such as liver cirrhosis, chronic renal failure, or heart valvulopathy, presented more severe disease requiring blood transfusions (OR 6.37 95% Cl 1.39-29.2, P= 0.015). The number of blood transfusions correlated with the number of sites affected (R = 0.35, P = 0.002). The detection of new lesions at capsule endoscopy allowed new treatment in 46% of patients. Mean follow-up was 18 months. Conclusions: Sporadic telangiectasia is a multifocal disease potentially involving the whole digestive tract. Patients with duodenal telangiectasia show a higher risk of jejunal or ileal lesions. Capsule endoscopy is a useful diagnostic tool for the detection of such small-bowel vascular lesions, indicating a more specific prognosis and treatment strategy.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalEndoscopy
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Digestive System Endoscopy
Capsule Endoscopy
Telangiectasis
Colonoscopy
Blood Transfusion
Blood Vessels
Gastrointestinal Tract
Odds Ratio
Hemorrhagic Disorders
Liver Cirrhosis
Chronic Kidney Failure
Hemorrhage

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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Gastrointestinal telangiectasia : A study by EGD, colonoscopy, and capsule endoscopy in 75 patients. / Polese, Lino; D'Incà, R.; Angriman, I.; Scarpa, M.; Pagano, D.; Ruffolo, C.; Lamboglia, F.; Stumiolo, G. C.; D'Amico, D. F.; Norberto, L.

In: Endoscopy, Vol. 40, No. 1, 01.2008, p. 23-29.

Research output: Contribution to journalArticle

Polese, L, D'Incà, R, Angriman, I, Scarpa, M, Pagano, D, Ruffolo, C, Lamboglia, F, Stumiolo, GC, D'Amico, DF & Norberto, L 2008, 'Gastrointestinal telangiectasia: A study by EGD, colonoscopy, and capsule endoscopy in 75 patients', Endoscopy, vol. 40, no. 1, pp. 23-29. https://doi.org/10.1055/s-2007-967039
Polese, Lino ; D'Incà, R. ; Angriman, I. ; Scarpa, M. ; Pagano, D. ; Ruffolo, C. ; Lamboglia, F. ; Stumiolo, G. C. ; D'Amico, D. F. ; Norberto, L. / Gastrointestinal telangiectasia : A study by EGD, colonoscopy, and capsule endoscopy in 75 patients. In: Endoscopy. 2008 ; Vol. 40, No. 1. pp. 23-29.
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AU - Polese, Lino

AU - D'Incà, R.

AU - Angriman, I.

AU - Scarpa, M.

AU - Pagano, D.

AU - Ruffolo, C.

AU - Lamboglia, F.

AU - Stumiolo, G. C.

AU - D'Amico, D. F.

AU - Norberto, L.

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N2 - Background: The distribution of lesions in the gastrointestinal tract in patients with sporadic telangiectasia is at present unknown. Patients and methods: 75 patients with sporadic telangiectasia underwent esophagogastroduodenoscopy (EGD), capsule endoscopy, and colonoscopy. Endoscopic diagnosis of telangiectasia and gastrointestinal bleeding were required for enrollment in the study. Hemorrhagic diathesis, co-morbidity, number of blood transfusions, and subsequent management were also noted. Results: 35 of the patients presented with gastroduodenal vascular lesions, 51 with small-bowel lesions, and 28 with colonic lesions. 67 % of patients in whom EGD found telangiectasia also presented small-bowel vascular lesions at capsule endoscopy and 43 % colonic lesions at colonoscopy. 54% percent of patients with positive colonoscopy also presented gastroduodenal lesions and 48% small-bowel lesions. Patients with known duodenal lesions were more likely to have small-bowel lesions at capsule endoscopy (odds ratio [OR] 10.19, 95% CI 2.1-49.33, P = 0.003). Patients with associated diseases, such as liver cirrhosis, chronic renal failure, or heart valvulopathy, presented more severe disease requiring blood transfusions (OR 6.37 95% Cl 1.39-29.2, P= 0.015). The number of blood transfusions correlated with the number of sites affected (R = 0.35, P = 0.002). The detection of new lesions at capsule endoscopy allowed new treatment in 46% of patients. Mean follow-up was 18 months. Conclusions: Sporadic telangiectasia is a multifocal disease potentially involving the whole digestive tract. Patients with duodenal telangiectasia show a higher risk of jejunal or ileal lesions. Capsule endoscopy is a useful diagnostic tool for the detection of such small-bowel vascular lesions, indicating a more specific prognosis and treatment strategy.

AB - Background: The distribution of lesions in the gastrointestinal tract in patients with sporadic telangiectasia is at present unknown. Patients and methods: 75 patients with sporadic telangiectasia underwent esophagogastroduodenoscopy (EGD), capsule endoscopy, and colonoscopy. Endoscopic diagnosis of telangiectasia and gastrointestinal bleeding were required for enrollment in the study. Hemorrhagic diathesis, co-morbidity, number of blood transfusions, and subsequent management were also noted. Results: 35 of the patients presented with gastroduodenal vascular lesions, 51 with small-bowel lesions, and 28 with colonic lesions. 67 % of patients in whom EGD found telangiectasia also presented small-bowel vascular lesions at capsule endoscopy and 43 % colonic lesions at colonoscopy. 54% percent of patients with positive colonoscopy also presented gastroduodenal lesions and 48% small-bowel lesions. Patients with known duodenal lesions were more likely to have small-bowel lesions at capsule endoscopy (odds ratio [OR] 10.19, 95% CI 2.1-49.33, P = 0.003). Patients with associated diseases, such as liver cirrhosis, chronic renal failure, or heart valvulopathy, presented more severe disease requiring blood transfusions (OR 6.37 95% Cl 1.39-29.2, P= 0.015). The number of blood transfusions correlated with the number of sites affected (R = 0.35, P = 0.002). The detection of new lesions at capsule endoscopy allowed new treatment in 46% of patients. Mean follow-up was 18 months. Conclusions: Sporadic telangiectasia is a multifocal disease potentially involving the whole digestive tract. Patients with duodenal telangiectasia show a higher risk of jejunal or ileal lesions. Capsule endoscopy is a useful diagnostic tool for the detection of such small-bowel vascular lesions, indicating a more specific prognosis and treatment strategy.

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