GB virus type C infection in patients treated for childhood acute lymphoblastic leukemia

Maurizio Aricò, Morena Bissolati, Grazia Bossi, Margherita Asti, Antonella Cerino, Dísirée Caselli, A. Antonio Ricci, Catherine Klersy, Enrico Silini, Mario U. Mondelli

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Abstract

BACKGROUND: The purpose of this study was to determine the prevalence of GB virus type C (GBV-C) infection in subjects treated for childhood acute lymphoblastic leukemia (ALL) or non-Hodgkin's lymphoma. STUDY DESIGN AND METHODS: One hundred forty patients (82 males) aged 4 to 27 years (median, 11) diagnosed with ALL between 1976 and 1993, were prospectively followed for a median of 5 years (range, 0.1-17) after completion of therapy. Stored sera were tested for antibody to hepatitis C virus (HCV), HCV RNA, antibody to GBV-C E2 (anti-E2), and GBV-C RNA. RESULTS: Thirty-eight patients (27%) were exposed to GBV-C: 30 were positive for GBV-C RNA (mostly type 2) and 8 were positive for anti-E2. Anti-E2 and GBV-C RNA were mutually exclusive: 61 patients (43%) were positive for HCV RNA, 16 (11%) were coinfected with GBV- C and HCV. Alanine aminotransferase (ALT) levels were increased (>35 mU/mL) in 32 (23%) of 137:3 of 20 who were positive for GBV-C and negative for HCV, 7 of 15 who were positive for GBV-C and HCV, 15 of 44 who were negative for GBV-C and positive for HCV, and 7 of 58 who were negative for GBV-C and HCV (p

Original languageEnglish
Pages (from-to)212-217
Number of pages6
JournalTransfusion
Volume39
Issue number2
Publication statusPublished - 1999

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ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Aricò, M., Bissolati, M., Bossi, G., Asti, M., Cerino, A., Caselli, D., Ricci, A. A., Klersy, C., Silini, E., & Mondelli, M. U. (1999). GB virus type C infection in patients treated for childhood acute lymphoblastic leukemia. Transfusion, 39(2), 212-217.