GD3 glycosphingolipid contributes to Fas-mediated apoptosis via association with ezrin cytoskeletal protein

Anna Maria Giammarioli, Tina Garofalo, Maurizio Sorice, Roberta Misasi, Lucrezia Gambardella, Roberto Gradini, Stefano Fais, Antonio Pavan, Walter Malorni

Research output: Contribution to journalArticle

Abstract

Efficiency of Fas-mediated apoptosis of lymphoid cells is regulated, among other means, by a mechanism involving its association with ezrin, a cytoskeletal protein belonging to the 4.1 family of proteins. In the present work, we provide evidence for a further molecule that associates to ezrin in Fas-triggered apoptosis, the disialoganglioside GD3. In fact, as an early event, GD3 redistributed in membrane-associated domains in uropods and co-localized with ezrin. Co-immunoprecipitation analyses confirmed this result, indicating a GD3-ezrin association. Altogether, these results are suggestive for a role of GD3 in Fas/ezrin-mediated apoptosis, supporting the view that uropods contain a multimolecular signaling complex involved in Fas-mediated apoptosis.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalFEBS Letters
Volume506
Issue number1
DOIs
Publication statusPublished - Sep 28 2001

Keywords

  • Apoptosis
  • Ezrin
  • Fas
  • Ganglioside
  • GD3

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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