Gel dosimetry in the BNCT facility for extra-corporeal treatment of liver cancer at the HFR Petten

Grazia Gambarini, G. G. Daquino, R. L. Moss, M. Carrara, V. A. Nievaart, E. Vanossi

Research output: Contribution to journalArticle

Abstract

A thorough evaluation of the dose inside a specially designed and built facility for extra-corporeal treatment of liver cancer by boron neutron capture therapy (BNCT) at the High Flux Reactor (HFR) Petten (The Netherlands) is the necessary step before animal studies can start. The absorbed doses are measured by means of gel dosemeters, which help to validate the Monte Carlo simulations of the spheroidal liver holder that will contain the human liver for irradiation with an epithermal neutron beam. These dosemeters allow imaging of the dose due to gammas and to the charged particles produced by the 10B reaction. The thermal neutron flux is extrapolated from the boron dose images and compared to that obtained by the calculations. As an additional reference, Au, Cu and Mn foil measurements are performed. All results appear consistent with the calculations and confirm that the BNCT liver facility is able to provide an almost homogeneous thermal neutron distribution in the liver, which is a requirement for a successful treatment of liver metastases.

Original languageEnglish
Pages (from-to)604-609
Number of pages6
JournalRadiation Protection Dosimetry
Volume126
Issue number1-4
DOIs
Publication statusPublished - 2007

Fingerprint

Boron Neutron Capture Therapy
Liver Neoplasms
liver
dosimeters
therapy
boron
cancer
Gels
reactors
gels
Neutrons
neutrons
Liver
dosage
thermal neutrons
Hot Temperature
Therapeutics
Boron
neutron distribution
Netherlands

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation
  • Public Health, Environmental and Occupational Health

Cite this

Gel dosimetry in the BNCT facility for extra-corporeal treatment of liver cancer at the HFR Petten. / Gambarini, Grazia; Daquino, G. G.; Moss, R. L.; Carrara, M.; Nievaart, V. A.; Vanossi, E.

In: Radiation Protection Dosimetry, Vol. 126, No. 1-4, 2007, p. 604-609.

Research output: Contribution to journalArticle

Gambarini, Grazia ; Daquino, G. G. ; Moss, R. L. ; Carrara, M. ; Nievaart, V. A. ; Vanossi, E. / Gel dosimetry in the BNCT facility for extra-corporeal treatment of liver cancer at the HFR Petten. In: Radiation Protection Dosimetry. 2007 ; Vol. 126, No. 1-4. pp. 604-609.
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