Gelastic epilepsy without hypothalamic hamartoma: Three additional cases

Salvatore Savasta, Mauro Budetta, Maria Valentina Spartà, Maria Luisa Carpentieri, Guido Trasimeni, Niki Zavras, Maria Pia Villa, Pasquale Parisi

Research output: Contribution to journalArticlepeer-review


We describe three children with gelastic seizures without hypothalamic hamartoma whose seizures were characterized by typical laughing attacks associated or not with other seizure types. Ictal/interictal EEG and magnetic resonance imaging were performed. All three subjects showed a good response to carbamazepine therapy with complete seizure control in addition to a benign clinical and cognitive outcome. These three cases confirm that gelastic epilepsy without hypothalamic hamartoma, both in cryptogenic or symptomatic patients (one child showed a dysplastic right parietotemporal lesion), usually has a more benign natural history, and carbamazepine seems to be the most efficacious therapy to obtain both immediate and long-term seizure control. These findings need to be confirmed in a larger sample of children affected by gelastic epilepsy without hypothalamic hamartoma.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalEpilepsy and Behavior
Publication statusPublished - 2014


  • Cryptogenic epilepsy
  • Focal epilepsy
  • Gelastic epilepsy
  • Gelastic seizures
  • Hypothalamic hamartoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology
  • Medicine(all)


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