Sindrome crisi gelastiche-amartoma ipotalamico: Studio di cinque casi

Translated title of the contribution: Gelastic seizures-hypothalamic hamartoma syndrome: Study on five patients

C. Nocerino, L. Bilo, R. Meo, S. Cirillo, P. Ruosi, V. Loreto, A. Estraneo, A. Mariniello, P. Striano, C. Burlato, S. Striano

Research output: Contribution to journalArticle

Abstract

Purpose: to describe characteristics and clinical evolution of Epilepsy in patients with gelastic seizures and hypotalamic hamartoma. Methods: ten patients observed between 1986 and 1998 with onset of the epileptic disorder and/or the most relevant element of seizure semeiology characterized by typical laughing attacks. Selection criteria included EEG or Video-EEG and MRI study. Results: five patients were affected by Symptomatic Localization Related Epilepsy, related to a hypotalamic hamartoma. This epileptic syndrome was usually drug-resistant. Two patients were surgically treated with good efficacy on seizure frequency. None of five patients presented precocious puberty. Conclusions: We confirm that the frequent finding of hypotalamic hamartoma in gelastic seizures. However, gelastic seizures may also be observed in patients without MRI lesions and with normal neurological status. In these patients clinical and EEG seizure semeiology is similar to symptomatic cases, but clinical evolution is usually more benign.

Translated title of the contributionGelastic seizures-hypothalamic hamartoma syndrome: Study on five patients
Original languageItalian
Pages (from-to)227-231
Number of pages5
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number102-103
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Clinical Neurology

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    Nocerino, C., Bilo, L., Meo, R., Cirillo, S., Ruosi, P., Loreto, V., Estraneo, A., Mariniello, A., Striano, P., Burlato, C., & Striano, S. (1998). Sindrome crisi gelastiche-amartoma ipotalamico: Studio di cinque casi. Bollettino - Lega Italiana contro l'Epilessia, (102-103), 227-231.