TY - JOUR
T1 - Gemcitabine and liposomal doxorubicin in biliary and hepatic carcinoma (HCC) chemotherapy
T2 - Preliminary results and review of the literature
AU - Pastorelli, D.
AU - Cartei, G.
AU - Zustovich, F.
AU - Marchese, F.
AU - Artioli, G.
AU - Zovato, S.
AU - Binato, S.
AU - Ceravolo, R.
AU - Cingarlini, S.
AU - Salmaso, F.
AU - Mattiazzi, M.
AU - Sanavio, C.
AU - Farinati, F.
AU - Zanus, G.
AU - Cillo, U.
PY - 2006/5
Y1 - 2006/5
N2 - Background: Advanced biliary tract cancers have a poor prognosis. Gemcitabine (G) as a single agent or in combination represents an active treatment option. Systemic chemotherapy in hepatocellular carcinoma represents a palliative treatment. Gemcitabine in combination with Liposomal Doxorubicin (LD) may represent an active treatment option. Pa tients and methods: Clinical trials for biliary and hepatic carcinoma have been reviewed. Results: We obtained RC (1 pt), RP (4 pts), SD (8 pts) and seven pts had PD (RR 25% and SD 40%). Our chemotherapy regimen was Gemcitabine 1000 mg/m2 d 1 and 8, Liposomal Doxorubicin 30 mg d 1, q 28. Patients were 21 (17 M), aged 44 to 78 (median 63 yrs). Only in 8 pts we observed G 3-4 haematological toxicity, thrombocytopenia and neutropenia (7 G3, 1 G4).
AB - Background: Advanced biliary tract cancers have a poor prognosis. Gemcitabine (G) as a single agent or in combination represents an active treatment option. Systemic chemotherapy in hepatocellular carcinoma represents a palliative treatment. Gemcitabine in combination with Liposomal Doxorubicin (LD) may represent an active treatment option. Pa tients and methods: Clinical trials for biliary and hepatic carcinoma have been reviewed. Results: We obtained RC (1 pt), RP (4 pts), SD (8 pts) and seven pts had PD (RR 25% and SD 40%). Our chemotherapy regimen was Gemcitabine 1000 mg/m2 d 1 and 8, Liposomal Doxorubicin 30 mg d 1, q 28. Patients were 21 (17 M), aged 44 to 78 (median 63 yrs). Only in 8 pts we observed G 3-4 haematological toxicity, thrombocytopenia and neutropenia (7 G3, 1 G4).
KW - Biliary tract cancers
KW - Chemotherapy
KW - Hepatocellular carcinoma
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U2 - 10.1093/annonc/mdj972
DO - 10.1093/annonc/mdj972
M3 - Article
C2 - 16807446
AN - SCOPUS:33745597366
VL - 17
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - SUPPL. 5
ER -