Gemcitabine and liposomal doxorubicin in the salvage treatment of ovarian cancer: Updated results and long-term survival

Gabriella Ferrandina, Ida Paris, Manuela Ludovisi, Giuseppe D'Agostino, Antonia Testa, Domenica Lorusso, Mariangela Zanghi, Salvatore Pisconti, Giuseppa Pezzella, Vincenzo Adamo, Enrico Breda, Giovanni Scambia

Research output: Contribution to journalArticle

Abstract

Objective. The combination of GEM/PLD has been tested for its efficacy on survival of recurrent ovarian cancer patients. Methods. This is a multicenter phase II study of GEM/PLD regimen in recurrent ovarian cancer patients previously treated with at least one platinum/paclitaxel regimen, and with evidence of measurable disease. PLD, 30 mg m-2, was administered on day 1 followed by GEM, 1000 mg m-2, on days 1 and 8, every 21 days. Results. 106 patients were available for response evaluation. 9 complete responses (8.5%) and 27 partial responses (25.5%) have been registered. 36 patients (34.0%) experienced stabilization of disease, while 34 (32.1%) cases progressed during treatment. OS was significantly shorter in platinum-resistant (median OS = 50 weeks) than in platinum-sensitive patients (median OS = 92 weeks) (P value = 0.0016). In the group of platinum-sensitive patients, cases responsive to GEM/PLD combination showed a better OS with respect to patients unresponsive to GEM/PLD (median OS = 120 weeks versus median OS = 60 weeks, P value = 0.019). The same trend was observed in platinum-resistant patients. Grade 4 hematological toxicity affected 20 patients (18%). Grade 3 palmar-plantar erythrodysesthesia (PPE) was registered in 16 patients (14.4%). Grades 3 and 4 mucositis was documented in 16 (14.4%) and 2 (1.8%) patients, respectively. Conclusions. GEM/PLD combination represents a valid approach in recurrent ovarian cancer patients. The hematological toxicity was easily managed, and the incidence and severity of PPE was low.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalGynecologic Oncology
Volume98
Issue number2
DOIs
Publication statusPublished - Aug 2005

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Keywords

  • Gemcitabine
  • Liposomal doxorubicin
  • Recurrent ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Ferrandina, G., Paris, I., Ludovisi, M., D'Agostino, G., Testa, A., Lorusso, D., Zanghi, M., Pisconti, S., Pezzella, G., Adamo, V., Breda, E., & Scambia, G. (2005). Gemcitabine and liposomal doxorubicin in the salvage treatment of ovarian cancer: Updated results and long-term survival. Gynecologic Oncology, 98(2), 267-273. https://doi.org/10.1016/j.ygyno.2005.04.018