TY - JOUR
T1 - Gemcitabine in epithelial ovarian cancer treatment
T2 - Current role and future perspectives
AU - Lorusso, D.
AU - Ferrandina, G.
AU - Fruscella, E.
AU - Marini, L.
AU - Adamo, V.
AU - Scambia, Giovanni
PY - 2005/11
Y1 - 2005/11
N2 - Newer agents and combinations are needed in order to improve current results in ovarian cancer treatment. Gemcitabine is a novel agent that has shown consistent activity as a single agent in the treatment of platinum-resistant ovarian cancer and a favorable toxicity profile. Because of its clinical and preclinical synergism with platinum analogs, gemcitabine has been combined with carboplatin as a convincing approach in the treatment of platinum-sensitive recurrent ovarian cancer patients. Further combination of gemcitabine and other agents, including paclitaxel, is also feasible and has been actively studied in order to establish the role of gemcitabine in the management of treated and untreated ovarian cancer patients.
AB - Newer agents and combinations are needed in order to improve current results in ovarian cancer treatment. Gemcitabine is a novel agent that has shown consistent activity as a single agent in the treatment of platinum-resistant ovarian cancer and a favorable toxicity profile. Because of its clinical and preclinical synergism with platinum analogs, gemcitabine has been combined with carboplatin as a convincing approach in the treatment of platinum-sensitive recurrent ovarian cancer patients. Further combination of gemcitabine and other agents, including paclitaxel, is also feasible and has been actively studied in order to establish the role of gemcitabine in the management of treated and untreated ovarian cancer patients.
KW - Gemcitabine
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=30944443523&partnerID=8YFLogxK
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U2 - 10.1111/j.1525-1438.2005.00331.x
DO - 10.1111/j.1525-1438.2005.00331.x
M3 - Article
C2 - 16343176
AN - SCOPUS:30944443523
VL - 15
SP - 1002
EP - 1013
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
SN - 1048-891X
IS - 6
ER -