Gemcitabine-induced systematic capillary leak syndrome

Research output: Contribution to journalArticle

Abstract

Systemic capillary leak syndrome (SCLS) is a rare disorder with a high mortality rate, characterized by rapidly developing edema, weight gain and hypotension, hemoconcentration and hypoproteinemia. This syndrome is caused by sudden, reversible capillary hyperpermeability with a rapid extravasation of plasma from the intravascular to the interstitial space. Even though SCLS has been suggested to be the pathogenic mechanism for the pulmonary toxicity of gemcitabine (GCB), a new deoxycytidine analogue with structural similarities to cytosine arabinoside, a direct correlation between GCB and SCLS has never been reported. We describe a case of repeated SCLS after GCB administration in a 51-year-old male with locally-advanced non-small-cell lung cancer treated with a combination of cisplatin and GCB. The detection of GCB-induced SCLS supports the hypothesis that SCLS could be the pathogenic way of GCB pulmonary toxicity. This finding can help to better understand and treat the potentially deadly GCB-related acute respiratory distress syndrome that is being recognized.

Original languageEnglish
Pages (from-to)1651-1652
Number of pages2
JournalAnnals of Oncology
Volume12
Issue number11
DOIs
Publication statusPublished - 2001

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Keywords

  • Capillary leak syndrome
  • Chemotherapy
  • Gemcitabine
  • Pulmonary toxicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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