Geminin: A major DNA replication safeguard in higher eukaryotes

Marina Melixetian, Kristian Helin

Research output: Contribution to journalArticlepeer-review

Abstract

Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.

Original languageEnglish
Pages (from-to)1002-1004
Number of pages3
JournalCell Cycle
Volume3
Issue number8
Publication statusPublished - Aug 2004

Keywords

  • Checkpoint
  • DNA replication
  • Geminin
  • Genomic instability
  • Rereplication

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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