Abstract
after being in the therapeutic wilderness for several decades, acute myeloid leukemia has been recently thrust into the limelight with a series of drug approvals. Technical refinements in production, genetic manipulation and chemical modification of monoclonal antibodies led to growing interest in antibodies-based treatment strategies. Much of the focus of these efforts in acute myeloid leukemia has been on cd33 as a target. On September 2, 2017, the U.S. Food and drug administration approved gemtuzumab ozogamicin for treatment of relapsed or refractory cd33+ acute myeloid leukemia. This signals a new chapter in the long and unusual story of gemtuzumab ozogamicin, which was the first antibody-drug conjugate approved for human use by the Food and drug administration. in this review we have analyzed the history of this drug which, among several mishaps, is experiencing a second youth and still represents a field to be further explored.
Original language | English |
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Pages (from-to) | 395-410 |
Number of pages | 16 |
Journal | Minerva Medica |
Volume | 111 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2020 |
Keywords
- Acute; Gemtuzumab; clinical Trials as topic; Biomarkers
- Leukemia
- Myeloid