Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies

Malgorzata E. Krzyszczak, Yi Li, Steven J. Ross, Angela Ceribelli, Edward K L Chan, Michael R. Bubb, Eric S. Sobel, Westley H. Reeves, Minoru Satoh

Research output: Contribution to journalArticle

Abstract

Autoantibodies to topoisomerase I (topo I), RNA polymerase III (RNAPIII), centromere, U3RNP/fibrillarin, Th, PM-Scl, and U1RNP found in scleroderma (SSc) are associated with unique clinical subsets. The effects of race and gender on autoantibody prevalence and clinical manifestations were examined. Autoantibodies in sera from 105 SSc (include 75 Caucasian, 24 African-American, 6 others; 89 females and 16 males) were analyzed by immunofluorescence and immunoprecipitation. Clinical information was from database. SSc-related autoantibodies seldom coexist except for anti-topo I and anti-U1RNP. Anti-topo I (35% vs 15%), anti-U3RNP (30% vs 3%, p∈=∈0.0005), and anti-U1RNP (30% vs 13%) were more common in African-Americans vs Caucasians. Anti-centromere (17%) and anti-PM-Scl (only in 8% of female) were found only in Caucasians. In race/gender combination, all three African-American males had anti-topo I (p∈=∈0.04). Anti-U3RNP (35% vs 3%, p∈=∈0.0005) and anti-U1RNP were common in African-American females. In African-American, all nucleolar dominant staining sera had anti-U3RNP; nuclear pattern was topo I (50%), U1RNP (19%), and RNAPIII (13%). In Caucasian, nucleolar was anti-Th (43%) and PM-Scl (29%); nuclear pattern was RNAPIII (29%), topo I (24%), and U1RNP (18%). Anti-topo I, anti-RNAPIII, and anti-U3RNP were associated with diffuse SSc while anti-centromere, anti-Th, and anti-U1 with limited disease. Proximal scleroderma was less common in African-American with anti-topo I (38% vs 91% in Caucasian, p∈=∈0.04). The production of SSc-related autoantibodies is gender and race dependent, and this can be highly relevant in understanding their clinical significance.

Original languageEnglish
Pages (from-to)1333-1339
Number of pages7
JournalClinical Rheumatology
Volume30
Issue number10
DOIs
Publication statusPublished - Oct 2011

    Fingerprint

Keywords

  • Autoantibodies
  • Gender
  • Race
  • Scleroderma
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Krzyszczak, M. E., Li, Y., Ross, S. J., Ceribelli, A., Chan, E. K. L., Bubb, M. R., Sobel, E. S., Reeves, W. H., & Satoh, M. (2011). Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies. Clinical Rheumatology, 30(10), 1333-1339. https://doi.org/10.1007/s10067-011-1751-0