Gender difference in drug use in hospitalized elderly patients

Paola Santalucia, Carlotta Franchi, Codjo D. Djade, Mauro Tettamanti, Luca Pasina, Salvatore Corrao, Francesco Salerno, Alessandra Marengoni, Maura Marcucci, Alessandro Nobili, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose The aims of this study were to evaluate whether or not there are gender differences in drug use at hospital admission and prescription at discharge and to evaluate the effect of hospitalization on medication patterns in the elderly. Method In-patients aged > 65 years included in the REPOSI registry during a recruitment period of 3 years (2008-2010-2012) were analyzed in order to evaluate drug use at hospital admission and prescription at discharge according to gender. Results A total of 3473 patients, 52% women and 48% men, were considered. Polypharmacy (> 5 drugs) is more frequent in men both at hospital admission and discharge. At hospital discharge, the number of prescriptions increased in both sexes at all age groups. Neuropsychiatric drugs were significantly more prescribed in women (p <0.0001). At admission men were more likely to be on antiplatelets (41.7% vs 36.7%; p = 0.0029), ACE-inhibitors (28.7% vs 24.7%; p = 0.0072) and statins (22.9% vs 18.3%; p = 0.0008). At discharge, antiplatelets (43.7% vs 37.3%; p = 0.0003) and statins (25,2% vs 19.6%; p <0.0001) continued to be prescribed more often in men, while women were given beta-blockers more often than men (21.8% vs 18.9%; p = 0.0340). Proton pump inhibitors were the most prescribed drugs regardless of gender. At discharge, the medication pattern did not change according to gender. Conclusion Our study showed a gender difference in overall medications pattern in the hospitalized elderly. Hospitalization, while increasing the number of prescriptions, did not change drug distribution by sex.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalEuropean Journal of Internal Medicine
Volume26
Issue number7
DOIs
Publication statusPublished - Sep 1 2015

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Prescriptions
Pharmaceutical Preparations
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hospitalization
Polypharmacy
Sex Distribution
Proton Pump Inhibitors
Angiotensin-Converting Enzyme Inhibitors
Registries
Age Groups

Keywords

  • Elderly
  • Gender
  • Polypharmacy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Gender difference in drug use in hospitalized elderly patients. / Santalucia, Paola; Franchi, Carlotta; Djade, Codjo D.; Tettamanti, Mauro; Pasina, Luca; Corrao, Salvatore; Salerno, Francesco; Marengoni, Alessandra; Marcucci, Maura; Nobili, Alessandro; Mannucci, Pier Mannuccio.

In: European Journal of Internal Medicine, Vol. 26, No. 7, 01.09.2015, p. 483-490.

Research output: Contribution to journalArticle

Santalucia, Paola ; Franchi, Carlotta ; Djade, Codjo D. ; Tettamanti, Mauro ; Pasina, Luca ; Corrao, Salvatore ; Salerno, Francesco ; Marengoni, Alessandra ; Marcucci, Maura ; Nobili, Alessandro ; Mannucci, Pier Mannuccio. / Gender difference in drug use in hospitalized elderly patients. In: European Journal of Internal Medicine. 2015 ; Vol. 26, No. 7. pp. 483-490.
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AU - Santalucia, Paola

AU - Franchi, Carlotta

AU - Djade, Codjo D.

AU - Tettamanti, Mauro

AU - Pasina, Luca

AU - Corrao, Salvatore

AU - Salerno, Francesco

AU - Marengoni, Alessandra

AU - Marcucci, Maura

AU - Nobili, Alessandro

AU - Mannucci, Pier Mannuccio

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N2 - Purpose The aims of this study were to evaluate whether or not there are gender differences in drug use at hospital admission and prescription at discharge and to evaluate the effect of hospitalization on medication patterns in the elderly. Method In-patients aged > 65 years included in the REPOSI registry during a recruitment period of 3 years (2008-2010-2012) were analyzed in order to evaluate drug use at hospital admission and prescription at discharge according to gender. Results A total of 3473 patients, 52% women and 48% men, were considered. Polypharmacy (> 5 drugs) is more frequent in men both at hospital admission and discharge. At hospital discharge, the number of prescriptions increased in both sexes at all age groups. Neuropsychiatric drugs were significantly more prescribed in women (p <0.0001). At admission men were more likely to be on antiplatelets (41.7% vs 36.7%; p = 0.0029), ACE-inhibitors (28.7% vs 24.7%; p = 0.0072) and statins (22.9% vs 18.3%; p = 0.0008). At discharge, antiplatelets (43.7% vs 37.3%; p = 0.0003) and statins (25,2% vs 19.6%; p <0.0001) continued to be prescribed more often in men, while women were given beta-blockers more often than men (21.8% vs 18.9%; p = 0.0340). Proton pump inhibitors were the most prescribed drugs regardless of gender. At discharge, the medication pattern did not change according to gender. Conclusion Our study showed a gender difference in overall medications pattern in the hospitalized elderly. Hospitalization, while increasing the number of prescriptions, did not change drug distribution by sex.

AB - Purpose The aims of this study were to evaluate whether or not there are gender differences in drug use at hospital admission and prescription at discharge and to evaluate the effect of hospitalization on medication patterns in the elderly. Method In-patients aged > 65 years included in the REPOSI registry during a recruitment period of 3 years (2008-2010-2012) were analyzed in order to evaluate drug use at hospital admission and prescription at discharge according to gender. Results A total of 3473 patients, 52% women and 48% men, were considered. Polypharmacy (> 5 drugs) is more frequent in men both at hospital admission and discharge. At hospital discharge, the number of prescriptions increased in both sexes at all age groups. Neuropsychiatric drugs were significantly more prescribed in women (p <0.0001). At admission men were more likely to be on antiplatelets (41.7% vs 36.7%; p = 0.0029), ACE-inhibitors (28.7% vs 24.7%; p = 0.0072) and statins (22.9% vs 18.3%; p = 0.0008). At discharge, antiplatelets (43.7% vs 37.3%; p = 0.0003) and statins (25,2% vs 19.6%; p <0.0001) continued to be prescribed more often in men, while women were given beta-blockers more often than men (21.8% vs 18.9%; p = 0.0340). Proton pump inhibitors were the most prescribed drugs regardless of gender. At discharge, the medication pattern did not change according to gender. Conclusion Our study showed a gender difference in overall medications pattern in the hospitalized elderly. Hospitalization, while increasing the number of prescriptions, did not change drug distribution by sex.

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