Gender differences in antiretroviral drug-related adipose tissue alterations: Women are at higher risk than men and develop particular lipodystrophy patterns

Massimo Galli, Fabrizio Veglia, Gioacchino Angarano, Sara Santambrogio, Elena Meneghini, Francesco Gritti, Antonietta Cargnel, Francesco Mazzotta, Adriano Lazzarin

Research output: Contribution to journalArticle

Abstract

Adipose tissue alterations (ATAs) were clinically assessed in 2258 HIV-1-infected outpatients consecutively observed in 6 Italian clinical centers and were found to be present in 29.5% of the men and 41.9% of the women. A logistic regression model including age, HIV disease Centers for Disease Control stage, CD4 cell counts, HIV RNA load, the duration of antiretroviral therapy, the number of drugs taken, and the use of d4T showed that men had a 0.47 adjusted risk of presenting with ATAs (95% CI: 0.38-0.58, P <0.0001). The risks of having ATAs (except circumscribed lipomas) in any body region, presenting with fat accumulation, or being affected by combined forms of ATA were also lower in men, whereas the risk of developing pure lipoatrophy was similar in the 2 genders. Our results indicate that women are at higher risk of developing antiretroviral treatment-related ATAs and show a particular and complex ATA pattern.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume34
Issue number1
DOIs
Publication statusPublished - Sep 1 2003

Keywords

  • Adipose tissue abnormalities
  • Antiretroviral treatment
  • Lipoatrophy

ASJC Scopus subject areas

  • Virology
  • Immunology

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