Gender differences in cardiovascular prophylaxis: Focus on antiplatelet treatment

Paolo Di Giosia, G. Passacquale, M. Petrarca, P. Giorgini, A.M. Marra, A. Ferro

Research output: Contribution to journalArticle

Abstract

Cardiovascular disease (CVD) represents the leading cause of death worldwide, and equally affects both sexes although women develop disease at an older age than men. A number of clinical evidence has identified the female sex as an independent factor for poor prognosis, with the rate of mortality and disability following an acute cardiovascular (CV) event being higher in women than men. It has been argued that the different level of platelet reactivity between sexes may account for a different responsiveness to anti-platelet therapy, with consequent important implications on clinical outcomes. However, conclusive evidence supporting the concept of a gender-dependent effectiveness of platelet inhibitors are lacking. On the contrary, sex-related dissimilarities have been evidenced in cardiovascular patients in terms of age of presentation, comorbidities such as obesity, diabetes and renal disease, and a different pharmacological approach to and effectiveness in controlling classical cardiovascular risk factors such as hypertension, glucose profile and lipid dysmetabolism. All these factors could place women at an increased level of cardiovascular risk compared to men, and may concur to an enhanced pro-thrombogenic profile. The purpose of this manuscript is to provide an overview of gender-related differences in cardiovascular treatment, in order to highlight the need to improve the pharmacological prophylaxis adopted in women through a more accurate evaluation of the overall cardiovascular risk profile with consequent establishment of a more effective and targeted anti-thrombotic strategy which is not limited to the use of anti-platelet agents. © 2017 Elsevier Ltd
Original languageEnglish
Pages (from-to)36-47
Number of pages12
JournalPharmacological Research
Volume119
DOIs
Publication statusPublished - 2017

Keywords

  • Antiplatelet treatment
  • Cardiovascular disease
  • Gender
  • Platelet

Fingerprint Dive into the research topics of 'Gender differences in cardiovascular prophylaxis: Focus on antiplatelet treatment'. Together they form a unique fingerprint.

  • Cite this