Background: In Ethiopia data concerning the influence of gender on death associated with HIV/AIDS and loss to follow-up in care and treatment are controversial. Objective: Our study intended to further investigate gender-related differences in antiretroviral therapy outcomes in Tigray (Ethiopia). Methods: We used data from the "Cohort of African People Starting Antiretroviral therapy' project, a prospective study of a cohort of HIV-positive patients who started ART in Tigray. The study population included HIV-positive patients starting antiretroviral therapy between January 2013 and December 2015. We compared baseline characteristics between men and women using Kruskal Wallis t-test and Chi-squared test. We employed Kaplan-Meier method to estimate the probability of mortality and loss to follow-up for men and women and univariate and multivariate Cox Proportional Hazards models to compare differences in antiretroviral therapy outcomes by gender. Results: The study population included 1,622 patients, 1,003 (61.8%) women and 619 (38.2%) men. Median follow -up time was 2.6 years and 2.1 years, respectively for women and men. In the multivariate analysis men had a significantly higher risk of loss to follow-up than women (aHR 2.8, 95% CI: 2.00-4.01); but no significant sex differences in mortality was observed (aHR 1.2, 95% CI: 0.76-1.84). Conclusions: Findings showed gender-related differences in loss to follow-up, not in mortality. Several structural and social factors may influence the gender difference in loss to follow-up. However, specific investigations are needed to get a better understanding of the reasons why men are more likely to be lost to follow-up than women and programmes with a gender-oriented approach should be implemented.
|Number of pages||7|
|Journal||Ethiopian Medical Journal|
|Publication status||Published - Jul 2019|
- Antiretroviral treatment
- Gender difference
- Loss- to follow-up
ASJC Scopus subject areas