Gender differences in Parkinson's disease: Focus on plasma alpha-synuclein

Giovanni Caranci, Paola Piscopo, Roberto Rivabene, Anna Traficante, Barbara Riozzi, Anna Elisa Castellano, Stefano Ruggieri, Nicola Vanacore, Annamaria Confaloni

Research output: Contribution to journalArticle

Abstract

Among promising biological markers proposed for Parkinson's disease (PD) and other disorders related to Lewy bodies, plasma alpha-synuclein assay has provided conflicting results mainly owing to the various laboratory assay techniques used and protein forms assayed. In this observational and exploratory cross-sectional study, using an immunoenzymatic technique, we assayed and compared total plasma alpha-synuclein concentrations in 69 patients with PD and 110 age-matched healthy control subjects. Two previously unreported findings concerned gender. First, plasma alpha-synuclein concentrations measured in the more advanced parkinsonian disease stages decreased in men, but not in women. Second, again only in men, plasma alpha-synuclein concentration was associated with cognitive impairments, hallucinations, and sleep disorders. These findings underline the gender-related differences in parkinsonian patients and indicate plasma alpha-synuclein expression as a potential biological marker for PD progression in men.

Original languageEnglish
Pages (from-to)1209-1215
Number of pages7
JournalJournal of Neural Transmission
Volume120
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Alpha-synuclein
  • Biomarker
  • Cognitive impairment
  • Parkinson's disease

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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  • Cite this

    Caranci, G., Piscopo, P., Rivabene, R., Traficante, A., Riozzi, B., Castellano, A. E., Ruggieri, S., Vanacore, N., & Confaloni, A. (2013). Gender differences in Parkinson's disease: Focus on plasma alpha-synuclein. Journal of Neural Transmission, 120(8), 1209-1215. https://doi.org/10.1007/s00702-013-0972-6