Gender differences in patients undergoing TAVI: A multicentre study

Fabrizio D'Ascenzo, Anna Gonella, Claudio Moretti, Pierluigi Omede, Stefano Salizzoni, Michele La Torre, Francesca Giordana, Marco Barbanti, Gian Paolo Ussia, Nedy Brambilla, Francesco Bedogni, Fiorenzo Gaita, Corrado Tamburino, Imad Sheiban

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: In patients undergoing surgical valve replacement for severe aortic stenosis, female gender was associated with worse outcomes, not persisting after multivariable adjustment for baseline clinical differences, while contrasting data are reported about TAVI. Methods and results: From January 2007 to December 2011 all patients with severe symptomatic aortic stenosis undergoing TAVI at our institutions were included in the present study, and were divided into two cohorts according to their gender. All endpoints were adjudicated according to VARC definition. Three hundred and seventy-seven patients were included: 161 male and 216 female. Male patients reported higher rates of previous coronary revascularisation, while both ejection fraction and mean aortic gradient were higher in female patients. At 30 days, rates of cardiovascular death were similar (6.0% vs. 8.1%; p=0.793), while overall bleedings (44% vs. 25%; p=0.024) and life-threatening bleedings (21.1% vs. 12.7%, p=0.016) were higher in female patients, also after multivariate analysis (OR 3.44; 1.23-9.22, and OR 2.1; 1.1-4.0, CI: 95%, respectively). Major vascular complications showed a tendency to be higher in female patients (12.9% vs. 9.8%, p=0.449). At a mean follow-up of 490±250 days, no significant difference was reported between men and women for all endpoints, and after multivariate adjustment only life-threatening bleeding was reported as a predictor of death (OR 8.2:3.8-17, CI: 95%). Conclusions: TAVI can be an effective and safe strategy in high surgical risk patients, regardless of the gender; life-threatening bleedings were reported more frequently in female patients, being the only independent predictor of death.

Original languageEnglish
Pages (from-to)367-372
Number of pages6
JournalEuroIntervention
Volume9
Issue number3
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Gender
  • Midterm outcome
  • TAVI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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