Abstract
We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1150-1156 |
| Number of pages | 7 |
| Journal | Movement Disorders |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jun 15 2007 |
Fingerprint
Keywords
- Deep brain stimulation
- Gender
- Parkinson's disease
- Subthalamic nucleus
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation. / Accolla, Ettore; Caputo, Elena; Cogiamanian, Filippo; Tamma, Filippo; Mrakic-Sposta, Simona; Marceglia, Sara; Egidi, Marcello; Rampini, Paolo; Locatelli, Marco; Priori, Alberto.
In: Movement Disorders, Vol. 22, No. 8, 15.06.2007, p. 1150-1156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation
AU - Accolla, Ettore
AU - Caputo, Elena
AU - Cogiamanian, Filippo
AU - Tamma, Filippo
AU - Mrakic-Sposta, Simona
AU - Marceglia, Sara
AU - Egidi, Marcello
AU - Rampini, Paolo
AU - Locatelli, Marco
AU - Priori, Alberto
PY - 2007/6/15
Y1 - 2007/6/15
N2 - We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.
AB - We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.
KW - Deep brain stimulation
KW - Gender
KW - Parkinson's disease
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=34447574624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447574624&partnerID=8YFLogxK
U2 - 10.1002/mds.21520
DO - 10.1002/mds.21520
M3 - Article
C2 - 17469208
AN - SCOPUS:34447574624
VL - 22
SP - 1150
EP - 1156
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 8
ER -