Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Ettore Accolla, Elena Caputo, Filippo Cogiamanian, Filippo Tamma, Simona Mrakic-Sposta, Sara Marceglia, Marcello Egidi, Paolo Rampini, Marco Locatelli, Alberto Priori

Research output: Contribution to journalArticlepeer-review


We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.

Original languageEnglish
Pages (from-to)1150-1156
Number of pages7
JournalMovement Disorders
Issue number8
Publication statusPublished - Jun 15 2007


  • Deep brain stimulation
  • Gender
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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