Abstract
Background: Higher mesothelioma rates in men (vs women) reflect more frequent and more intense asbestos exposure. We assessed the impact of exposure difference between genders on age-specific rates of pleural mesothelioma (PM) occurrence using data from two Italian regions. Methods: We used data from the Lombardy and Piedmont mesothelioma registries (period 2000–2016, age 45–74 years) to compare rates of PM in men and women and to estimate the rate advancement period (RAP). Results: Based on 3384 cases (2405 men, 979 women) in Lombardy and 2042 (1389 men, 653 women) in Piedmont, the rate ratio was 2.81 (90% confidence interval: 2.61–3.03) in Lombardy and 2.39 (2.17–2.62) in Piedmont. In both regions RAP ranged from 7 to 10 years (at age 45 and 63 in men, respectively). Conclusion: Men showed more than twofold increased PM rates and reached the same incidence as women 7–10 years earlier. RAP can be a useful measure of exposure impact on premature disease occurrence.
| Original language | English |
|---|---|
| Article number | 108636 |
| Journal | Environmental Research |
| Volume | 177 |
| DOIs | |
| Publication status | Published - Oct 1 2019 |
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Keywords
- Asbestos
- Pleural mesothelioma
- Rate advancement period
- Rate ratio
ASJC Scopus subject areas
- Biochemistry
- Environmental Science(all)
Cite this
Gender differences in pleural mesothelioma occurrence in Lombardy and Piedmont, Italy. / Consonni, D.; Migliore, Enrica; Barone-Adesi, Francesco; Dallari, Barbara; De Matteis, Sara; Oddone, Enrico; Pesatori, Angela C.; Riboldi, Luciano; Mirabelli, D.; Mensi, Carolina.
In: Environmental Research, Vol. 177, 108636, 01.10.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gender differences in pleural mesothelioma occurrence in Lombardy and Piedmont, Italy
AU - Consonni, D.
AU - Migliore, Enrica
AU - Barone-Adesi, Francesco
AU - Dallari, Barbara
AU - De Matteis, Sara
AU - Oddone, Enrico
AU - Pesatori, Angela C.
AU - Riboldi, Luciano
AU - Mirabelli, D.
AU - Mensi, Carolina
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Higher mesothelioma rates in men (vs women) reflect more frequent and more intense asbestos exposure. We assessed the impact of exposure difference between genders on age-specific rates of pleural mesothelioma (PM) occurrence using data from two Italian regions. Methods: We used data from the Lombardy and Piedmont mesothelioma registries (period 2000–2016, age 45–74 years) to compare rates of PM in men and women and to estimate the rate advancement period (RAP). Results: Based on 3384 cases (2405 men, 979 women) in Lombardy and 2042 (1389 men, 653 women) in Piedmont, the rate ratio was 2.81 (90% confidence interval: 2.61–3.03) in Lombardy and 2.39 (2.17–2.62) in Piedmont. In both regions RAP ranged from 7 to 10 years (at age 45 and 63 in men, respectively). Conclusion: Men showed more than twofold increased PM rates and reached the same incidence as women 7–10 years earlier. RAP can be a useful measure of exposure impact on premature disease occurrence.
AB - Background: Higher mesothelioma rates in men (vs women) reflect more frequent and more intense asbestos exposure. We assessed the impact of exposure difference between genders on age-specific rates of pleural mesothelioma (PM) occurrence using data from two Italian regions. Methods: We used data from the Lombardy and Piedmont mesothelioma registries (period 2000–2016, age 45–74 years) to compare rates of PM in men and women and to estimate the rate advancement period (RAP). Results: Based on 3384 cases (2405 men, 979 women) in Lombardy and 2042 (1389 men, 653 women) in Piedmont, the rate ratio was 2.81 (90% confidence interval: 2.61–3.03) in Lombardy and 2.39 (2.17–2.62) in Piedmont. In both regions RAP ranged from 7 to 10 years (at age 45 and 63 in men, respectively). Conclusion: Men showed more than twofold increased PM rates and reached the same incidence as women 7–10 years earlier. RAP can be a useful measure of exposure impact on premature disease occurrence.
KW - Asbestos
KW - Pleural mesothelioma
KW - Rate advancement period
KW - Rate ratio
UR - http://www.scopus.com/inward/record.url?scp=85070563411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070563411&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2019.108636
DO - 10.1016/j.envres.2019.108636
M3 - Article
AN - SCOPUS:85070563411
VL - 177
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 108636
ER -