TY - JOUR
T1 - Gender effects on plasma PGRN levels in patients with Alzheimer's disease
T2 - A preliminary study
AU - Piscopo, Paola
AU - Rivabene, Roberto
AU - Galimberti, Daniela
AU - Crestini, Alessio
AU - Talarico, Giuseppina
AU - Vanacore, Nicola
AU - Scarpini, Elio
AU - Bruno, Giuseppe
AU - Confaloni, Annamaria
PY - 2013
Y1 - 2013
N2 - Plasma progranulin (PGRN) levels constitute a potentially invaluable biomarker for neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and, perhaps, Alzheimer's disease (AD). We assessed plasma PGRN levels in 107 AD patients, 36 FTLD patients, and 107 controls. We found that, in female AD patients, there is a positive correlation between PGRN levels and age. Although no significant differences were found between patients and controls, we observed higher levels in females compared to males; in AD patients, a positive correlation between PGRN levels and age was observed in females. In conclusion, our data suggest that PGRN may not be a good biomarker for AD; moreover, gender may influence the plasma PGRN levels of AD patients.
AB - Plasma progranulin (PGRN) levels constitute a potentially invaluable biomarker for neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and, perhaps, Alzheimer's disease (AD). We assessed plasma PGRN levels in 107 AD patients, 36 FTLD patients, and 107 controls. We found that, in female AD patients, there is a positive correlation between PGRN levels and age. Although no significant differences were found between patients and controls, we observed higher levels in females compared to males; in AD patients, a positive correlation between PGRN levels and age was observed in females. In conclusion, our data suggest that PGRN may not be a good biomarker for AD; moreover, gender may influence the plasma PGRN levels of AD patients.
KW - Alzheimer's disease
KW - gender
KW - plasma
KW - progranulin
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U2 - 10.3233/JAD-121606
DO - 10.3233/JAD-121606
M3 - Article
C2 - 23396349
AN - SCOPUS:84877145860
VL - 35
SP - 313
EP - 318
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -