Gender effects on plasma PGRN levels in patients with Alzheimer's disease: A preliminary study

Paola Piscopo, Roberto Rivabene, Daniela Galimberti, Alessio Crestini, Giuseppina Talarico, Nicola Vanacore, Elio Scarpini, Giuseppe Bruno, Annamaria Confaloni

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma progranulin (PGRN) levels constitute a potentially invaluable biomarker for neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and, perhaps, Alzheimer's disease (AD). We assessed plasma PGRN levels in 107 AD patients, 36 FTLD patients, and 107 controls. We found that, in female AD patients, there is a positive correlation between PGRN levels and age. Although no significant differences were found between patients and controls, we observed higher levels in females compared to males; in AD patients, a positive correlation between PGRN levels and age was observed in females. In conclusion, our data suggest that PGRN may not be a good biomarker for AD; moreover, gender may influence the plasma PGRN levels of AD patients.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalJournal of Alzheimer's Disease
Volume35
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Alzheimer's disease
  • gender
  • plasma
  • progranulin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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