'Gender gap' in multiple sclerosis: Magnetic resonance imaging evidence

Carlo Pozzilli, V. Tomassini, F. Marinelli, A. Paolillo, C. Gasperini, S. Bastianello

Research output: Contribution to journalArticlepeer-review


The authors evaluated the gender difference in the magnetic resonance imaging characteristics of the lesions occurring in the brain of 413 multiple sclerosis (MS) patients. Men had fewer contrast-enhancing lesions (P 1/4 0.01), but a higher proportion of lesions evolving into 'black holes' (P 1/4 0.001), when compared with women. Thus, our data indicate that men with MS are prone to develop less inflammatory, but more destructive lesions than women. This study results provides support for a modulation of the MS pathological changes by gender.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalEuropean Journal of Neurology
Issue number1
Publication statusPublished - 2003


  • Gender difference
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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