'Gender gap' in multiple sclerosis: Magnetic resonance imaging evidence

Carlo Pozzilli, V. Tomassini, F. Marinelli, A. Paolillo, C. Gasperini, S. Bastianello

Research output: Contribution to journalArticle


The authors evaluated the gender difference in the magnetic resonance imaging characteristics of the lesions occurring in the brain of 413 multiple sclerosis (MS) patients. Men had fewer contrast-enhancing lesions (P 1/4 0.01), but a higher proportion of lesions evolving into 'black holes' (P 1/4 0.001), when compared with women. Thus, our data indicate that men with MS are prone to develop less inflammatory, but more destructive lesions than women. This study results provides support for a modulation of the MS pathological changes by gender.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalEuropean Journal of Neurology
Issue number1
Publication statusPublished - 2003


  • Gender difference
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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