Gender-related differences in catheter ablation of atrial fibrillation

Giovanni B. Forleo, Claudio Tondo, Lucia De Luca, Antonio Dello Russo, Michela Casella, Valerio De Sanctis, Fabrizio Clementi, Rafael Lopes Fagundes, Roberto Leo, Francesco Romeo, Massimo Mantica

Research output: Contribution to journalArticlepeer-review


Aims: Women have an increased risk for atrial fibrillation (AF)-related complications and there is evidence towards a reduced efficacy of the rhythm control strategy than men. A catheter-based strategy is therefore widely attractive, but the impact of gender on catheter ablation (CA) of AF remains undefined. Methods and results: We included 221 consecutive patients (150 men) who underwent CA of drug-refractory AF. Gender differences in clinical presentation and outcomes were compared. Women were older (P = 0.002), had a longer history of AF (P = 0.04), and were more likely to have hypertension (P = 0.04). Moreover, a concomitant valvular heart disease tended to be more common in women (32.4 vs. 23.3%; P = 0.28) and left atrium dimensions were significantly larger (P = 0.003). However, acute success rate and complications rate were similar between genders. After 22.5 ± 11.8 months of follow-up, the overall freedom from arrhythmia recurrences was similar (83.1 vs. 82.7% in men), and a similar improvement in SF-36 quality of life scores was achieved in both groups. Conclusion: Women are referred for AF ablation later with a more complex clinical pre-operative presentation. Despite this higher risk profile in women, no differences were detected in clinical outcomes. Our findings indicate that CA of AF appears to be safe and effective in women as in men.

Original languageEnglish
Pages (from-to)613-620
Number of pages8
Issue number8
Publication statusPublished - Aug 2007


  • Arrhythmia
  • Atrial fibrillation
  • Catheter ablation
  • Gender

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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