Gender-related differences in response to mutagens and carcinogens

M. Kirsch-Volders, S. Bonassi, Z. Herceg, A. Hirvonen, L. Möller, D. H. Phillips

Research output: Contribution to journalArticlepeer-review


The incidences of many cancers can be very different in men and women. Besides differences in exposures to putative causative agents, it is plausible that both genetic and epigenetic effects play roles in these differences. In addition, gender-specific lifestyle and behavioural factors may modulate the effects of exposure to genotoxins. This commentary focuses on several aspects of gender-related differences in responses to mutagens and carcinogens, including sensitivity to chromosome damage, the contribution of genotypic variation and the role of DNA methylation. It is concluded that the reasons for gender differences in cancer susceptibility remain largely unknown in many cases, and the subject deserves more attention and study.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
Issue number3
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Toxicology
  • Health, Toxicology and Mutagenesis


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