Gender-related disparities in non-small cell lung cancer

Marco G. Paggi, Rosa Vona, Claudia Abbruzzese, Walter Malorni

Research output: Contribution to journalArticlepeer-review


Epidemiological studies clearly outline some disparities in cancer onset, progression as well as prognosis and therapeutic response between sexes. In particular, in lung cancer, the leading cause of cancer death, at least in Western countries, a gender disparity appears now to emerge, especially for non-small cell lung cancer (NSCLC). Such a disparity is apparently due to a variety of mechanisms, ranging from genetic and epigenetic differences to gender-specific lifestyle as well as to behavioral causes and, clearly, to sex hormones activity. Here we briefly recapitulate gender differences in terms of risk factors, histopathological features and pathogenetic mechanisms in NSCLC, and hypothesize that a gender-oriented pharmacology could beneficially impact on innovative therapeutic strategies.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCancer Letters
Issue number1
Publication statusPublished - Dec 2010


  • Apoptosis
  • Autophagy
  • Cancer
  • Estrogens
  • Gender
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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