Abstract
Background: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-ε4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. Objective: To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. Methods: Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognitively normal and impaired. All patients were genotyped for APOE gene polymorphisms. Results: Fifty-six percent of MS patients showed, to different extents, cognitive impairment. Cognitive decline was predominant in men and was associated with disease duration, Kurtzke Expanded Disability Status Scale (EDSS) score, a low level of education, and, interestingly, the ε4 allele of the APOE gene. By contrast, cognitive impairment in women was independent of any investigated variable. Conclusion: The findings demonstrate that clinical and genetic factors play a role in men affected by MS developing cognitive impairment.
| Original language | English |
|---|---|
| Pages (from-to) | 1208-1214 |
| Number of pages | 7 |
| Journal | Journal of Neurology |
| Volume | 251 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2004 |
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Keywords
- APOE
- Cognitive impairment
- Multiple sclerosis
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. / Savettieri, Giovanni; Messina, Demetrio; Andreoli, Virginia; Bonavita, Simona; Caltagirone, Carlo; Cittadella, Rita; Farina, Deborah; Fazio, Maria Carolina; Girlanda, Paolo; Le Pira, Francesco; Liguori, Maria; Lugaresi, Alessandra; Nocentini, Ugo; Reggio, Arturo; Salemi, Giuseppe; Tedeschi, Gioacchino; Trojano, Maria; Valentino, Paola; Quattrone, Aldo.
In: Journal of Neurology, Vol. 251, No. 10, 10.2004, p. 1208-1214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
AU - Savettieri, Giovanni
AU - Messina, Demetrio
AU - Andreoli, Virginia
AU - Bonavita, Simona
AU - Caltagirone, Carlo
AU - Cittadella, Rita
AU - Farina, Deborah
AU - Fazio, Maria Carolina
AU - Girlanda, Paolo
AU - Le Pira, Francesco
AU - Liguori, Maria
AU - Lugaresi, Alessandra
AU - Nocentini, Ugo
AU - Reggio, Arturo
AU - Salemi, Giuseppe
AU - Tedeschi, Gioacchino
AU - Trojano, Maria
AU - Valentino, Paola
AU - Quattrone, Aldo
PY - 2004/10
Y1 - 2004/10
N2 - Background: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-ε4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. Objective: To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. Methods: Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognitively normal and impaired. All patients were genotyped for APOE gene polymorphisms. Results: Fifty-six percent of MS patients showed, to different extents, cognitive impairment. Cognitive decline was predominant in men and was associated with disease duration, Kurtzke Expanded Disability Status Scale (EDSS) score, a low level of education, and, interestingly, the ε4 allele of the APOE gene. By contrast, cognitive impairment in women was independent of any investigated variable. Conclusion: The findings demonstrate that clinical and genetic factors play a role in men affected by MS developing cognitive impairment.
AB - Background: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-ε4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. Objective: To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. Methods: Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognitively normal and impaired. All patients were genotyped for APOE gene polymorphisms. Results: Fifty-six percent of MS patients showed, to different extents, cognitive impairment. Cognitive decline was predominant in men and was associated with disease duration, Kurtzke Expanded Disability Status Scale (EDSS) score, a low level of education, and, interestingly, the ε4 allele of the APOE gene. By contrast, cognitive impairment in women was independent of any investigated variable. Conclusion: The findings demonstrate that clinical and genetic factors play a role in men affected by MS developing cognitive impairment.
KW - APOE
KW - Cognitive impairment
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=8744251003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8744251003&partnerID=8YFLogxK
U2 - 10.1007/s00415-004-0508-y
DO - 10.1007/s00415-004-0508-y
M3 - Article
VL - 251
SP - 1208
EP - 1214
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 10
ER -