Abstract
To investigate associations between gender and myocardial involvement in systemic amyloidosis, we reviewed all patients presenting between 1994 and September 2006 in our institutional network (100 AL and 98 familial transthyretin-related amyloidosis (ATTR) patients, plus 12 elderly men with senile systemic amyloidosis). We focused on echocardiographic descriptors of myocardial involvement (height-indexed mean left ventricular (LV) wall thickness, LV mass index), and baseline LV function. Among familial ATTR patients, female prevalence was lower within the highest tertile of either echocardiographic indicator of myocardial involvement. Gender was independently associated with height-indexed mean LV wall thickness (as were gene mutations). Female prevalence appeared rather similar across the different neurological stages. Within the subgroup of familial ATTR patients with amyloidotic cardiomyopathy, women tended to display a considerably less severe morphological and functional echocardiographic profile. We explored the possible role of female sex hormones by considering menopausal status: women in the highest tertile of mean LV wall thickness index were more often postmenopausal than those in the other two tertiles and had a much higher (∼15 years) mean age; analogous age-related associations were not observable for men. In conclusion, these findings raise the hypothesis that some biological characteristic associated with female gender protects against myocardial involvement in familial ATTR.
| Original language | English |
|---|---|
| Pages (from-to) | 40-48 |
| Number of pages | 9 |
| Journal | Amyloid |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2008 |
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Keywords
- Amyloidosis
- Cardiomyopathies
- Female
- Male
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
Cite this
Gender-related risk of myocardial involvement in systemic amyloidosis. / Rapezzi, Claudio; Riva, Letizia; Quarta, Cristina C.; Perugini, Enrica; Salvi, Fabrizio; Longhi, Simone; Ciliberti, Paolo; Pastorelli, Francesca; Biagini, Elena; Leone, Ornella; Cooke, Robin M T; Bacchi-Reggiani, Letizia; Ferlini, Alessandra; Cavo, Michele; Merlini, Giampaolo; Perlini, Stefano; Pasquali, Sonia; Branzi, Angelo.
In: Amyloid, Vol. 15, No. 1, 2008, p. 40-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gender-related risk of myocardial involvement in systemic amyloidosis
AU - Rapezzi, Claudio
AU - Riva, Letizia
AU - Quarta, Cristina C.
AU - Perugini, Enrica
AU - Salvi, Fabrizio
AU - Longhi, Simone
AU - Ciliberti, Paolo
AU - Pastorelli, Francesca
AU - Biagini, Elena
AU - Leone, Ornella
AU - Cooke, Robin M T
AU - Bacchi-Reggiani, Letizia
AU - Ferlini, Alessandra
AU - Cavo, Michele
AU - Merlini, Giampaolo
AU - Perlini, Stefano
AU - Pasquali, Sonia
AU - Branzi, Angelo
PY - 2008
Y1 - 2008
N2 - To investigate associations between gender and myocardial involvement in systemic amyloidosis, we reviewed all patients presenting between 1994 and September 2006 in our institutional network (100 AL and 98 familial transthyretin-related amyloidosis (ATTR) patients, plus 12 elderly men with senile systemic amyloidosis). We focused on echocardiographic descriptors of myocardial involvement (height-indexed mean left ventricular (LV) wall thickness, LV mass index), and baseline LV function. Among familial ATTR patients, female prevalence was lower within the highest tertile of either echocardiographic indicator of myocardial involvement. Gender was independently associated with height-indexed mean LV wall thickness (as were gene mutations). Female prevalence appeared rather similar across the different neurological stages. Within the subgroup of familial ATTR patients with amyloidotic cardiomyopathy, women tended to display a considerably less severe morphological and functional echocardiographic profile. We explored the possible role of female sex hormones by considering menopausal status: women in the highest tertile of mean LV wall thickness index were more often postmenopausal than those in the other two tertiles and had a much higher (∼15 years) mean age; analogous age-related associations were not observable for men. In conclusion, these findings raise the hypothesis that some biological characteristic associated with female gender protects against myocardial involvement in familial ATTR.
AB - To investigate associations between gender and myocardial involvement in systemic amyloidosis, we reviewed all patients presenting between 1994 and September 2006 in our institutional network (100 AL and 98 familial transthyretin-related amyloidosis (ATTR) patients, plus 12 elderly men with senile systemic amyloidosis). We focused on echocardiographic descriptors of myocardial involvement (height-indexed mean left ventricular (LV) wall thickness, LV mass index), and baseline LV function. Among familial ATTR patients, female prevalence was lower within the highest tertile of either echocardiographic indicator of myocardial involvement. Gender was independently associated with height-indexed mean LV wall thickness (as were gene mutations). Female prevalence appeared rather similar across the different neurological stages. Within the subgroup of familial ATTR patients with amyloidotic cardiomyopathy, women tended to display a considerably less severe morphological and functional echocardiographic profile. We explored the possible role of female sex hormones by considering menopausal status: women in the highest tertile of mean LV wall thickness index were more often postmenopausal than those in the other two tertiles and had a much higher (∼15 years) mean age; analogous age-related associations were not observable for men. In conclusion, these findings raise the hypothesis that some biological characteristic associated with female gender protects against myocardial involvement in familial ATTR.
KW - Amyloidosis
KW - Cardiomyopathies
KW - Female
KW - Male
UR - http://www.scopus.com/inward/record.url?scp=39049117075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049117075&partnerID=8YFLogxK
U2 - 10.1080/13506120701815373
DO - 10.1080/13506120701815373
M3 - Article
C2 - 18266120
AN - SCOPUS:39049117075
VL - 15
SP - 40
EP - 48
JO - Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
JF - Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
SN - 1350-6129
IS - 1
ER -