Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

Aurelia Santoro, Giulia Guidarelli, Rita Ostan, Enrico Giampieri, Cristina Fabbri, Claudia Bertarelli, Claudio Nicoletti, Fawzi Kadi, Lisette C P G M de Groot, Edith Feskens, Agnes Berendsen, Anna Brzozowska, Olga Januszko, Katarzyna Kozlowska, Susan Fairweather-Tait, Amy Jennings, Nathalie Meunier, Elodie Caumon, Alessandro Napoli, Daniele MercatelliGiuseppe Battista, Miriam Capri, Claudio Franceschi, Alberto Bazzocchi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.

METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.

RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.

CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.

KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalEuropean Radiology
DOIs
Publication statusE-pub ahead of print - Feb 4 2019

Fingerprint

Body Composition
Receptors, Tumor Necrosis Factor, Type II
Interleukin-10
Sarcopenia
Interleukin-6
Skeletal Muscle
Anti-Inflammatory Agents
Photon Absorptiometry
Interleukin-1
Adipose Tissue
Resistin
Orosomucoid
Bone and Bones
Ghrelin
Adiponectin
Leptin
Immunoassay
Albumins
Glycoproteins
Biomarkers

Keywords

  • Aging
  • Body composition
  • DXA
  • Inflammation
  • Sarcopenia

Cite this

Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. / Santoro, Aurelia; Guidarelli, Giulia; Ostan, Rita; Giampieri, Enrico; Fabbri, Cristina; Bertarelli, Claudia; Nicoletti, Claudio; Kadi, Fawzi; de Groot, Lisette C P G M; Feskens, Edith; Berendsen, Agnes; Brzozowska, Anna; Januszko, Olga; Kozlowska, Katarzyna; Fairweather-Tait, Susan; Jennings, Amy; Meunier, Nathalie; Caumon, Elodie; Napoli, Alessandro; Mercatelli, Daniele; Battista, Giuseppe; Capri, Miriam; Franceschi, Claudio; Bazzocchi, Alberto.

In: European Radiology, 04.02.2019, p. 1-12.

Research output: Contribution to journalArticle

Santoro, A, Guidarelli, G, Ostan, R, Giampieri, E, Fabbri, C, Bertarelli, C, Nicoletti, C, Kadi, F, de Groot, LCPGM, Feskens, E, Berendsen, A, Brzozowska, A, Januszko, O, Kozlowska, K, Fairweather-Tait, S, Jennings, A, Meunier, N, Caumon, E, Napoli, A, Mercatelli, D, Battista, G, Capri, M, Franceschi, C & Bazzocchi, A 2019, 'Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study', European Radiology, pp. 1-12. https://doi.org/10.1007/s00330-018-5973-2
Santoro, Aurelia ; Guidarelli, Giulia ; Ostan, Rita ; Giampieri, Enrico ; Fabbri, Cristina ; Bertarelli, Claudia ; Nicoletti, Claudio ; Kadi, Fawzi ; de Groot, Lisette C P G M ; Feskens, Edith ; Berendsen, Agnes ; Brzozowska, Anna ; Januszko, Olga ; Kozlowska, Katarzyna ; Fairweather-Tait, Susan ; Jennings, Amy ; Meunier, Nathalie ; Caumon, Elodie ; Napoli, Alessandro ; Mercatelli, Daniele ; Battista, Giuseppe ; Capri, Miriam ; Franceschi, Claudio ; Bazzocchi, Alberto. / Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. In: European Radiology. 2019 ; pp. 1-12.
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T1 - Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

AU - Santoro, Aurelia

AU - Guidarelli, Giulia

AU - Ostan, Rita

AU - Giampieri, Enrico

AU - Fabbri, Cristina

AU - Bertarelli, Claudia

AU - Nicoletti, Claudio

AU - Kadi, Fawzi

AU - de Groot, Lisette C P G M

AU - Feskens, Edith

AU - Berendsen, Agnes

AU - Brzozowska, Anna

AU - Januszko, Olga

AU - Kozlowska, Katarzyna

AU - Fairweather-Tait, Susan

AU - Jennings, Amy

AU - Meunier, Nathalie

AU - Caumon, Elodie

AU - Napoli, Alessandro

AU - Mercatelli, Daniele

AU - Battista, Giuseppe

AU - Capri, Miriam

AU - Franceschi, Claudio

AU - Bazzocchi, Alberto

PY - 2019/2/4

Y1 - 2019/2/4

N2 - OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.

AB - OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.

KW - Aging

KW - Body composition

KW - DXA

KW - Inflammation

KW - Sarcopenia

U2 - 10.1007/s00330-018-5973-2

DO - 10.1007/s00330-018-5973-2

M3 - Article

C2 - 30715588

SP - 1

EP - 12

JO - European Radiology

JF - European Radiology

SN - 0938-7994

ER -