Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study

Angelo Scuteri, Christopher H. Morrell, Marco Orru', Majid Alghatrif, Pier Sergio Saba, Antonio Terracciano, Liana Anna Pina Ferreli, Francesco Loi, Michele Marongiu, Maria Grazia Pilia, Alessandro Delitala, Kirill V. Tarasov, David Schlessinger, Antonello Ganau, Francesco Cucca, Edward G. Lakatta

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: There is no definite consensus on the CV burden associated to Masked hypertension (MH) or White Coat Hypertension (WCH)-conditions that can be detected by out-of-office blood pressure measurements (24 hour Ambulatory Blood Pressure Monitoring, 24 h ABPM). Methods: We investigated the association of WCH and MH with arterial aging, indexed by a range of parameters of large artery structure and function in 2962 subjects, taking no antihypertensive medications, who are participating in a large community-based population of both men and women over a broad age range (14-102 years). Results: The overall prevalence of WCH was 9.5% and was 5.0% for MH, with 54.9% of subjects classified as true normotensive and 30.6% as true hypertensive. Both WCH and MH were associated with a stiffer aorta, a less distensible and thicker common carotid artery, and greater central BP than true normotensive subjects. Notably, the profile of arterial alterations in WCH and MH did not significantly differ from what was observed in true hypertensive subjects. The arterial changes accompanying WCH and MH differed in men and women, with women showing a greater tendency towards concentric remodeling, greater parietal wall stress, and PWV than men. Conclusion: Both WCH, and MH are associatedwith early arterial aging, and therefore, neither can be regarded as innocent conditions. Future studies are required to establish whether measurement of arterial aging parameters in subjects with WCH or MHwill identify subjects at higher risk of CV events and cognitive impairment, who may require more clinical attention and pharmacological intervention.

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalInternational Journal of Cardiology
Volume217
DOIs
Publication statusPublished - Aug 15 2016

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Masked Hypertension
White Coat Hypertension
Italy
Ambulatory Blood Pressure Monitoring
Common Carotid Artery
Antihypertensive Agents
Aorta
Arteries
Pharmacology
Blood Pressure

Keywords

  • 24 hour blood pressure monitoring
  • Arterial aging
  • Arterial stiffness
  • Carotid thickness
  • Masked hypertension
  • Pulse wave velocity
  • White coat hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study. / Scuteri, Angelo; Morrell, Christopher H.; Orru', Marco; Alghatrif, Majid; Saba, Pier Sergio; Terracciano, Antonio; Ferreli, Liana Anna Pina; Loi, Francesco; Marongiu, Michele; Pilia, Maria Grazia; Delitala, Alessandro; Tarasov, Kirill V.; Schlessinger, David; Ganau, Antonello; Cucca, Francesco; Lakatta, Edward G.

In: International Journal of Cardiology, Vol. 217, 15.08.2016, p. 92-98.

Research output: Contribution to journalArticle

Scuteri, A, Morrell, CH, Orru', M, Alghatrif, M, Saba, PS, Terracciano, A, Ferreli, LAP, Loi, F, Marongiu, M, Pilia, MG, Delitala, A, Tarasov, KV, Schlessinger, D, Ganau, A, Cucca, F & Lakatta, EG 2016, 'Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study', International Journal of Cardiology, vol. 217, pp. 92-98. https://doi.org/10.1016/j.ijcard.2016.04.172
Scuteri, Angelo ; Morrell, Christopher H. ; Orru', Marco ; Alghatrif, Majid ; Saba, Pier Sergio ; Terracciano, Antonio ; Ferreli, Liana Anna Pina ; Loi, Francesco ; Marongiu, Michele ; Pilia, Maria Grazia ; Delitala, Alessandro ; Tarasov, Kirill V. ; Schlessinger, David ; Ganau, Antonello ; Cucca, Francesco ; Lakatta, Edward G. / Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study. In: International Journal of Cardiology. 2016 ; Vol. 217. pp. 92-98.
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AU - Scuteri, Angelo

AU - Morrell, Christopher H.

AU - Orru', Marco

AU - Alghatrif, Majid

AU - Saba, Pier Sergio

AU - Terracciano, Antonio

AU - Ferreli, Liana Anna Pina

AU - Loi, Francesco

AU - Marongiu, Michele

AU - Pilia, Maria Grazia

AU - Delitala, Alessandro

AU - Tarasov, Kirill V.

AU - Schlessinger, David

AU - Ganau, Antonello

AU - Cucca, Francesco

AU - Lakatta, Edward G.

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N2 - Background: There is no definite consensus on the CV burden associated to Masked hypertension (MH) or White Coat Hypertension (WCH)-conditions that can be detected by out-of-office blood pressure measurements (24 hour Ambulatory Blood Pressure Monitoring, 24 h ABPM). Methods: We investigated the association of WCH and MH with arterial aging, indexed by a range of parameters of large artery structure and function in 2962 subjects, taking no antihypertensive medications, who are participating in a large community-based population of both men and women over a broad age range (14-102 years). Results: The overall prevalence of WCH was 9.5% and was 5.0% for MH, with 54.9% of subjects classified as true normotensive and 30.6% as true hypertensive. Both WCH and MH were associated with a stiffer aorta, a less distensible and thicker common carotid artery, and greater central BP than true normotensive subjects. Notably, the profile of arterial alterations in WCH and MH did not significantly differ from what was observed in true hypertensive subjects. The arterial changes accompanying WCH and MH differed in men and women, with women showing a greater tendency towards concentric remodeling, greater parietal wall stress, and PWV than men. Conclusion: Both WCH, and MH are associatedwith early arterial aging, and therefore, neither can be regarded as innocent conditions. Future studies are required to establish whether measurement of arterial aging parameters in subjects with WCH or MHwill identify subjects at higher risk of CV events and cognitive impairment, who may require more clinical attention and pharmacological intervention.

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