TY - JOUR
T1 - Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis
AU - Costanza, Massimo
AU - Di Dario, Marco
AU - Steinman, Lawrence
AU - Farina, Cinthia
AU - Pedotti, Rosetta
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Along with their established role in allergic reactions, histamine and its receptors have been implicated in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis. In this study we analyzed the gene expression of histamine receptor 1 (HRH1), HRH2 and HRH4 in peripheral blood mononuclear cells derived from patients with clinically isolated syndrome (CIS), relapsing-remitting (RR) MS, secondary-progressive (SP) MS, primary-progressive (PP) MS, and healthy controls (HC). We found that HRH1 transcript was significantly down-modulated in SP-MS compared with HC, and HRH4 was increased in this group compared to HC, CIS and RR-MS. No other differences in the expression of histamine receptors were observed between HC, CIS and other clinical forms of definite MS.
AB - Along with their established role in allergic reactions, histamine and its receptors have been implicated in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis. In this study we analyzed the gene expression of histamine receptor 1 (HRH1), HRH2 and HRH4 in peripheral blood mononuclear cells derived from patients with clinically isolated syndrome (CIS), relapsing-remitting (RR) MS, secondary-progressive (SP) MS, primary-progressive (PP) MS, and healthy controls (HC). We found that HRH1 transcript was significantly down-modulated in SP-MS compared with HC, and HRH4 was increased in this group compared to HC, CIS and RR-MS. No other differences in the expression of histamine receptors were observed between HC, CIS and other clinical forms of definite MS.
KW - Histamine receptors
KW - Multiple sclerosis
KW - Peripheral blood mononuclear cells
UR - http://www.scopus.com/inward/record.url?scp=84919354741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919354741&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2014.09.018
DO - 10.1016/j.jneuroim.2014.09.018
M3 - Article
C2 - 25293806
AN - SCOPUS:84919354741
VL - 277
SP - 186
EP - 188
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -