Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis

Massimo Costanza, Marco Di Dario, Lawrence Steinman, Cinthia Farina, Rosetta Pedotti

Research output: Contribution to journalArticle

Abstract

Along with their established role in allergic reactions, histamine and its receptors have been implicated in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis. In this study we analyzed the gene expression of histamine receptor 1 (HRH1), HRH2 and HRH4 in peripheral blood mononuclear cells derived from patients with clinically isolated syndrome (CIS), relapsing-remitting (RR) MS, secondary-progressive (SP) MS, primary-progressive (PP) MS, and healthy controls (HC). We found that HRH1 transcript was significantly down-modulated in SP-MS compared with HC, and HRH4 was increased in this group compared to HC, CIS and RR-MS. No other differences in the expression of histamine receptors were observed between HC, CIS and other clinical forms of definite MS.

Original languageEnglish
Pages (from-to)186-188
Number of pages3
JournalJournal of Neuroimmunology
Volume277
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2014

Keywords

  • Histamine receptors
  • Multiple sclerosis
  • Peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

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