Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer

Maurizio Callari, Vera Cappelletti, Loris De Cecco, Valeria Musella, Patrizia Miodini, Silvia Veneroni, Manuela Gariboldi, Marco Alessandro Pierotti, Maria Grazia Daidone

Research output: Contribution to journalArticlepeer-review


Male breast cancer (MBC) is a poorly characterized disease because of its rarity. Clinical management is based on results obtained from randomized trials conducted in women notwithstanding data in the literature suggesting relevant gender-associated differences in terms of biological and clinical behavior. However, a genome-wide characterization of MBC on a transcriptional level is lacking. In this study, gene expression profiles of 37 estrogen receptor positive (ER+) MBC specimens were compared to that of 53 ER+ Female Breast Cancer (FBC) samples similar for clinical and patho-biological features. Almost 1000 genes were found differentially expressed (FDR <1%) between female and male patients and biological interpretation highlighted a gender-associated modulation of key biological processes ranging from energy metabolism to regulation of translation and matrix remodeling as well as immune system recruitment. Moreover, an analysis of genes correlated to steroid receptors and ERBB2 suggested a prominent role for the androgen receptor in MBC with a minor relevance for progesterone receptor and ERBB2, although, similarly to FBC, a genomic amplification could be observed. Our findings support the idea that breast cancer is a quite different disease in male and female patients and the underlying gender-related biological differences are likely to have clinical implications connected with different susceptibility to treatment.

Original languageEnglish
Pages (from-to)601-610
Number of pages10
JournalBreast Cancer Research and Treatment
Issue number3
Publication statusPublished - Jun 2011


  • Breast cancer
  • Gender differences
  • Gene expression profile
  • Male breast cancer
  • Pathway analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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