Gene expression changes in human cells after exposure to mobile phone microwaves

Daniel Remondini, Reetta Nylund, Jukka Reivinen, Florence Poulletier De Gannes, Bernard Veyret, Isabelle Lagroye, Emmanuelle Haro, M. Angeles Trillo, Miriam Capri, Claudio Franceschi, Kathrin Schlatterer, Richard Gminski, Rudolf Fitzner, Rudolf Tauber, Jurgen Schuderer, Niels Kuster, Dariusz Leszczynski, Ferdinando Bersani, Christian Maercker

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Possible biological effects of mobile phone microwaves were investigated in vitro. In this study, which was part of the 5FP EU project REFLEX (Risk Evaluation of Potential Environmental Hazards From Low-Energy Electromagnetic Field Exposure Using Sensitive in vitro Methods), six human cell types, immortalized cell lines and primary cells, were exposed to 900 and 1800 MHz. RNA was isolated from exposed and sham-exposed cells and labeled for transcriptome analysis on whole-genome cDNA arrays. The results were evaluated statistically using bioinformatics techniques and examined for biological relevance with the help of different databases. NB69 neuroblastoma cells, T lymphocytes, and CHME5 microglial cells did not show significant changes in gene expression. In EA.hy926 endothelial cells, U937 lymphoblastoma cells, and HL-60 leukemia cells we found between 12 and 34 up- or down-regulated genes. Analysis of the affected gene families does not point towards a stress response. However, following microwave exposure, some but not all human cells might react with an increase in expression of genes encoding ribosomal proteins and therefore up-regulating the cellular metabolism.

Original languageEnglish
Pages (from-to)4745-4754
Number of pages10
JournalProteomics
Volume6
Issue number17
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Cell Phones
Microwaves
Mobile phones
Gene expression
Genes
Cells
Gene Expression
Gene encoding
T-cells
Ribosomal Proteins
Endothelial cells
Bioinformatics
Metabolism
Electromagnetic fields
Hazards
Complementary DNA
RNA
U937 Cells
Electromagnetic Fields
HL-60 Cells

Keywords

  • Bioinformatics
  • Mobile phones
  • Radiofrequency electromagnetic fields
  • Transcriptome analysis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Remondini, D., Nylund, R., Reivinen, J., De Gannes, F. P., Veyret, B., Lagroye, I., ... Maercker, C. (2006). Gene expression changes in human cells after exposure to mobile phone microwaves. Proteomics, 6(17), 4745-4754. https://doi.org/10.1002/pmic.200500896

Gene expression changes in human cells after exposure to mobile phone microwaves. / Remondini, Daniel; Nylund, Reetta; Reivinen, Jukka; De Gannes, Florence Poulletier; Veyret, Bernard; Lagroye, Isabelle; Haro, Emmanuelle; Trillo, M. Angeles; Capri, Miriam; Franceschi, Claudio; Schlatterer, Kathrin; Gminski, Richard; Fitzner, Rudolf; Tauber, Rudolf; Schuderer, Jurgen; Kuster, Niels; Leszczynski, Dariusz; Bersani, Ferdinando; Maercker, Christian.

In: Proteomics, Vol. 6, No. 17, 09.2006, p. 4745-4754.

Research output: Contribution to journalArticle

Remondini, D, Nylund, R, Reivinen, J, De Gannes, FP, Veyret, B, Lagroye, I, Haro, E, Trillo, MA, Capri, M, Franceschi, C, Schlatterer, K, Gminski, R, Fitzner, R, Tauber, R, Schuderer, J, Kuster, N, Leszczynski, D, Bersani, F & Maercker, C 2006, 'Gene expression changes in human cells after exposure to mobile phone microwaves', Proteomics, vol. 6, no. 17, pp. 4745-4754. https://doi.org/10.1002/pmic.200500896
Remondini D, Nylund R, Reivinen J, De Gannes FP, Veyret B, Lagroye I et al. Gene expression changes in human cells after exposure to mobile phone microwaves. Proteomics. 2006 Sep;6(17):4745-4754. https://doi.org/10.1002/pmic.200500896
Remondini, Daniel ; Nylund, Reetta ; Reivinen, Jukka ; De Gannes, Florence Poulletier ; Veyret, Bernard ; Lagroye, Isabelle ; Haro, Emmanuelle ; Trillo, M. Angeles ; Capri, Miriam ; Franceschi, Claudio ; Schlatterer, Kathrin ; Gminski, Richard ; Fitzner, Rudolf ; Tauber, Rudolf ; Schuderer, Jurgen ; Kuster, Niels ; Leszczynski, Dariusz ; Bersani, Ferdinando ; Maercker, Christian. / Gene expression changes in human cells after exposure to mobile phone microwaves. In: Proteomics. 2006 ; Vol. 6, No. 17. pp. 4745-4754.
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