Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice

Andrew I. Su, Luca G. Guidotti, John Paul Pezacki, Francis V. Chisari, Peter G. Schultz

Research output: Contribution to journalArticle

Abstract

Understanding the gene-expression patterns during liver regeneration may help to reveal how regenerative processes are initiated and controlled as well as shed new light onto processes that lead to liver disease. Using high-density oligonucleotide arrays, we have examined the gene-expression program in the livers of mice after partial hepatectomy. A time course was constructed for gene expression between 0 and 4 h after partial hepatectomy, corresponding to the priming phase of liver regeneration. The genomic program for liver regeneration involves transcription-factor generation, stress and inflammatory responses, cytoskeletal and extracellular matrix modification, and regulation of cell-cycle entry. The genome-wide changes that are observed provide a detailed and comprehensive map of the initial priming stage of liver regeneration.

Original languageEnglish
Pages (from-to)11181-11186
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number17
DOIs
Publication statusPublished - Aug 20 2002

ASJC Scopus subject areas

  • Genetics
  • General

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