Gene expression in the Andes; relevance to neurology at sea level

Otto Appenzeller; Tamara Minko; Vitaly Pozharov; Maurizio Bonfichi; Luca Malcovati; Jorge Gamboa; Luciano Bernardi

doi:10.1016/S0022-510X(02)00356-8

Gene expression in the Andes; relevance to neurology at sea level

Otto Appenzeller, Tamara Minko, Vitaly Pozharov, Maurizio Bonfichi, Luca Malcovati, Jorge Gamboa, Luciano Bernardi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic mountain sickness (CMS), a maladaptation syndrome to chronic hypoxia, occurs in the Andes. Gene expression differences in Andeans could explain adaptation and maladaptation to hypoxia, both of which are relevant to neurology at sea level. Expression of genes responsive to cellular oxygen concentration, hypoxia-inducible factor-1α (HIF-1α), three splicing variants of vascular endothelial growth factor (VEGF) and von Hippel-Lindau protein (pVHL) was measured by reverse transcription polymerase chain reaction (RT-PCR) in 12 Cerro de Pasco (CP) (altitude 4338 m) natives and 15 CMS patients in CP. Thirteen high altitude natives living in Lima and five Lima natives were sea level controls. A CMS score (CMS-sc) was assigned clinically. Expression was related to the clinical assessment. High expression of HIF-1α and VEGF-121 was found in CMS (P

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	207
Issue number	1-2
DOIs	https://doi.org/10.1016/S0022-510X(02)00356-8
Publication status	Published - Mar 15 2003

Keywords

Aging
Gene expression in Andeans
Human chronic hypoxia
Nervous system

ASJC Scopus subject areas

Ageing
Clinical Neurology
Surgery
Developmental Neuroscience
Neurology
Neuroscience(all)

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title = "Gene expression in the Andes; relevance to neurology at sea level",

abstract = "Chronic mountain sickness (CMS), a maladaptation syndrome to chronic hypoxia, occurs in the Andes. Gene expression differences in Andeans could explain adaptation and maladaptation to hypoxia, both of which are relevant to neurology at sea level. Expression of genes responsive to cellular oxygen concentration, hypoxia-inducible factor-1α (HIF-1α), three splicing variants of vascular endothelial growth factor (VEGF) and von Hippel-Lindau protein (pVHL) was measured by reverse transcription polymerase chain reaction (RT-PCR) in 12 Cerro de Pasco (CP) (altitude 4338 m) natives and 15 CMS patients in CP. Thirteen high altitude natives living in Lima and five Lima natives were sea level controls. A CMS score (CMS-sc) was assigned clinically. Expression was related to the clinical assessment. High expression of HIF-1α and VEGF-121 was found in CMS (P",

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AU - Appenzeller, Otto

AU - Minko, Tamara

AU - Pozharov, Vitaly

AU - Bonfichi, Maurizio

AU - Malcovati, Luca

AU - Gamboa, Jorge

AU - Bernardi, Luciano

PY - 2003/3/15

Y1 - 2003/3/15

N2 - Chronic mountain sickness (CMS), a maladaptation syndrome to chronic hypoxia, occurs in the Andes. Gene expression differences in Andeans could explain adaptation and maladaptation to hypoxia, both of which are relevant to neurology at sea level. Expression of genes responsive to cellular oxygen concentration, hypoxia-inducible factor-1α (HIF-1α), three splicing variants of vascular endothelial growth factor (VEGF) and von Hippel-Lindau protein (pVHL) was measured by reverse transcription polymerase chain reaction (RT-PCR) in 12 Cerro de Pasco (CP) (altitude 4338 m) natives and 15 CMS patients in CP. Thirteen high altitude natives living in Lima and five Lima natives were sea level controls. A CMS score (CMS-sc) was assigned clinically. Expression was related to the clinical assessment. High expression of HIF-1α and VEGF-121 was found in CMS (P

AB - Chronic mountain sickness (CMS), a maladaptation syndrome to chronic hypoxia, occurs in the Andes. Gene expression differences in Andeans could explain adaptation and maladaptation to hypoxia, both of which are relevant to neurology at sea level. Expression of genes responsive to cellular oxygen concentration, hypoxia-inducible factor-1α (HIF-1α), three splicing variants of vascular endothelial growth factor (VEGF) and von Hippel-Lindau protein (pVHL) was measured by reverse transcription polymerase chain reaction (RT-PCR) in 12 Cerro de Pasco (CP) (altitude 4338 m) natives and 15 CMS patients in CP. Thirteen high altitude natives living in Lima and five Lima natives were sea level controls. A CMS score (CMS-sc) was assigned clinically. Expression was related to the clinical assessment. High expression of HIF-1α and VEGF-121 was found in CMS (P

KW - Aging

KW - Gene expression in Andeans

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KW - Nervous system

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Gene expression in the Andes; relevance to neurology at sea level

Abstract

Keywords

ASJC Scopus subject areas

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