Gene expression of fructosamine 3 kinase in patients with colorectal cancer

Maria Gabriella Caruso, Maria Notarnicola, Donato Francesco Altomare, Giovanni Misciagna

Research output: Contribution to journalArticle

Abstract

Objective: Spontaneous non-enzymatic reaction of protein amino groups with glucose and other reducing sugars, known as glycation or Maillard reaction, has long been considered irreversible and inevitably followed by slow conversion of fructosamines and advanced glycation end products. Instead, recent identification of fructosamine 3 kinase (FN3K) has unveiled that fructosamines can be physiologically repaired, so that the FN3K enzyme could be considered a new form of protein repair. Methods: Thirty-one consecutive patients with colorectal cancer were enrolled in the study. FN3K gene expression was determined using quantitative RT-PCR. Results: The mean level of FN3K gene expression was significantly lower in cancer tissue than in the corresponding normal colorectal mucosa, and FN3K gene was under-expressed most particularly in the tumours located on the left side of the colon. Conclusions: Low mRNA levels of this enzyme in colon cancer tissue with respect to normal surrounding mucosa suggests that neoplastic cells have lost a protective enzymatic system. Reduced FN3K gene expression may be important in the pathogenesis and progression of colorectal cancer.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalOncology
Volume73
Issue number1-2
DOIs
Publication statusPublished - Mar 2008

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Keywords

  • Colorectal cancer
  • Fructosamine 3 kinase
  • Gene expression
  • Glycation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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