Gene expression profile of endothelial cells during perturbation of the gut vascular barrier

Ilaria Spadoni, Alessandro Pietrelli, Graziano Pesole, Maria Rescigno

Research output: Contribution to journalArticle

Abstract

It has been widely demonstrated that tolerance against gut microbiota is compartmentalized to mucosal sites where microbes mostly reside. How the commensal bacteria are excluded from the entrance into the blood stream via intestinal capillaries that are located beneath the gut epithelium was not clear. We recently described the existence of a new anatomical structure, the ‘gut vascular barrier’ (GVB), both in murine and human intestines that plays a fundamental role in avoiding indiscriminate trafficking of bacteria from the gut into the blood circulation. The vascular barrier integrity could be altered by Salmonella typhimurium, a pathogen capable of systemic dissemination, through the modulation of the Wnt/β-catenin signaling pathway. Here we have analyzed the differences in gut endothelial gene expression profiles during Salmonella infection and have identified some interesting characteristics of endothelial to mesenchymal transition. These findings add new insights in the gut-liver axis.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalGut Microbes
DOIs
Publication statusAccepted/In press - Oct 18 2016

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Keywords

  • blood-brain barrier
  • celiac disease
  • gut-vascular barrier
  • intestinal endothelium
  • RNA-sequencing
  • Salmonella typhimurium

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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