Gene expression profiling in breast cancer: A clinical perspective

Grazia Arpino, Daniele Generali, Anna Sapino, Del Matro Lucia, Antonio Frassoldati, Michelino de Laurentis, Pronzato Paolo, Giorgio Mustacchi, Marina Cazzaniga, Sabino De Placido, Pierfranco Conte, Mariarosa Cappelletti, Vanessa Zanoni, Andrea Antonelli, Mario Martinotti, Fabio Puglisi, Alfredo Berruti, Alberto Bottini, Luigi Dogliotti

Research output: Contribution to journalArticlepeer-review

Abstract

Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalBreast
Volume22
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Breast cancer
  • Gene arrays
  • Gene profiles
  • Prognostic factors

ASJC Scopus subject areas

  • Surgery

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