Gene expression profiling in immune cells using microarray

Francesca Granucci, Paola Ricciardi Castagnoli, Lars Rogge, Francesco Sinigaglia

Research output: Contribution to journalArticle

Abstract

The recent development of DNA microarray, which offers the opportunity to study the expression of thousands of individual genes simultaneously in different biological systems, has provided new insights into the immune system. Examples discussed in this review include molecular descriptions of the differentiation program of T helper (Th) cells into Th1 and Th2 pathways and the genetic program underlying maturation of dendritic cells. It is anticipated that this new information can be used to understand gene function in both physiological and pathological conditions of the immune system.

Original languageEnglish
Pages (from-to)257-266
Number of pages10
JournalInternational Archives of Allergy and Immunology
Volume126
Issue number4
DOIs
Publication statusPublished - 2001

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Keywords

  • Dendritic cell
  • DNA microarray
  • T cell
  • T helper 1
  • T helper 2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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