Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma

Roberto Ria, Vittorio Simeon, Assunta Melaccio, Giovanna Di Meo, Stefania Trino, Carmela Mazzoccoli, Ilaria Saltarella, Aurelia Lamanuzzi, Annalisa Morano, Angela Gurrado, Alessandro Pasculli, Gaetano Lastilla, Pellegrino Musto, Antonia Reale, Franco Dammacco, Angelo Vacca, Mario Testini

Research output: Contribution to journalArticlepeer-review


Gene expression profiling (GEP) of normal thyroid tissue from 43 patients with thyroid carcinoma, 6 with thyroid adenoma, 42 with multinodular goiter, and 6 with Graves-Basedow disease was carried out with the aim of achieving a better understanding of the genetic mechanisms underlying the role of normal cells surrounding the tumor in the thyroid cancer progression. Unsupervised and supervised analyses were performed to compare samples from neoplastic and non-neoplastic diseases. GEP and subsequent RT-PCR analysis identified 28 differentially expressed genes. Functional assessment revealed that they are involved in tumorigenesis and cancer progression. The distinct GEP is likely to reflect the onset and/or progression of thyroid cancer, its molecular classification, and the identification of new potential prognostic factors, thus allowing to pinpoint selective gene targets with the aim of realizing more precise preoperative diagnostic procedures and novel therapeutic approaches.

Original languageEnglish
Pages (from-to)29677-29688
Number of pages12
Issue number20
Publication statusPublished - May 17 2016


  • Gene expression profile
  • Hypoxia
  • Microenvironment
  • Oncogenes
  • Thyroid cancer

ASJC Scopus subject areas

  • Oncology


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