Gene interference strategies as a new tool for the treatment of prostate cancer

Mariarosaria Boccellino, Concetta Alaia, Gabriella Misso, Alessia Maria Cossu, Gaetano Facchini, Raffaele Piscitelli, Lucio Quagliuolo, Michele Caraglia

Research output: Contribution to journalArticlepeer-review

Abstract

Prostate cancer (PCa) is one of the most common cancer in men. It affects older men and the incidence increases with age; the median age at diagnosis is 67 years. The diagnosis of PCa is essentially based on three tools: digital rectal exam, serum concentration of prostate specific antigen, and transrectal ultrasound-guided biopsy. Currently, the therapeutic treatments of this cancer are different and range from the prostatectomy to hormonal therapy, to radiation therapy, to immunotherapy, and to chemotherapy. However, additional efforts are required in order to find new weapons for the treatment of metastatic setting of disease. The purpose of this review is to highlight new therapeutic strategies based on gene interference; in fact, numerous siRNA and miRNA in the therapeutic treatment of PCa are reported below.

Original languageEnglish
Pages (from-to)588-605
Number of pages18
JournalEndocrine
Volume49
Issue number3
DOIs
Publication statusPublished - Aug 27 2015

Keywords

  • Androgen depletion therapy (ADT)
  • Epigenetics
  • microRNA (miRNA)
  • Prostate cancer (PCa)
  • small interfering RNA (siRNA)
  • Stabilized nucleic acid lipid particle (SNALP)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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