Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues

E. Petrangeli, C. Lubrano, L. Ravenna, A. Vacca, M. R. Cardillo, L. Salvatori, F. Sciarra, L. Frati, A. Gulino

Research output: Contribution to journalArticle

Abstract

Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic tissues, suggesting a significant role in neoplastic transformation.

Original languageEnglish
Pages (from-to)973-975
Number of pages3
JournalBritish Journal of Cancer
Volume72
Issue number4
Publication statusPublished - 1995

Keywords

  • Epidermal growth factor receptor
  • Gene methylation
  • Neoplastic breast tissue
  • Oestrogen receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Petrangeli, E., Lubrano, C., Ravenna, L., Vacca, A., Cardillo, M. R., Salvatori, L., Sciarra, F., Frati, L., & Gulino, A. (1995). Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues. British Journal of Cancer, 72(4), 973-975.