Plasma levels of α1-antichymotrypsin (ACT) and interleukin-1β (IL-1β) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-1β genes affected plasma levels of ACT or IL-1β, and AD patients with the ACT T,T or IL-1β T,T genotype showed the highest levels of plasma ACT or IL-1β, respectively. The concomitant presence of the ACT T,T and IL-1β T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.
|Number of pages||4|
|Journal||Annals of Neurology|
|Publication status||Published - 2000|
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