Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease

Evelyn Ferri; Beatrice Arosio; Claudio D'Addario; Daniela Galimberti; Cristina Gussago; Mariangela Pucci; Martina Casati; Chiara Fenoglio; Carlo Abbate; Paolo Dionigi Rossi; Elio Angelo Scarpini; Mauro Maccarrone; Daniela Mari

doi:10.1016/j.jns.2016.02.004

Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease

Evelyn Ferri, Beatrice Arosio, Claudio D'Addario, Daniela Galimberti, Cristina Gussago, Mariangela Pucci, Martina Casati, Chiara Fenoglio, Carlo Abbate, Paolo Dionigi Rossi, Elio Angelo Scarpini, Mauro Maccarrone, Daniela Mari

Research output: Contribution to journal › Article › peer-review

Abstract

Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.

Original language	English
Pages (from-to)	283-286
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	362
DOIs	https://doi.org/10.1016/j.jns.2016.02.004
Publication status	Published - Mar 15 2016

Keywords

Alzheimer's disease
Frontotemporal dementia
Methylation
Neurodegeneration
Peripheral marker
Pin1

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Ferri, E., Arosio, B., D'Addario, C., Galimberti, D., Gussago, C., Pucci, M., Casati, M., Fenoglio, C., Abbate, C., Rossi, P. D., Scarpini, E. A., Maccarrone, M., & Mari, D. (2016). Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease. Journal of the Neurological Sciences, 362, 283-286. https://doi.org/10.1016/j.jns.2016.02.004

Ferri, E, Arosio, B, D'Addario, C, Galimberti, D, Gussago, C, Pucci, M, Casati, M, Fenoglio, C, Abbate, C, Rossi, PD , Scarpini, EA , Maccarrone, M & Mari, D 2016, 'Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease', Journal of the Neurological Sciences, vol. 362, pp. 283-286. https://doi.org/10.1016/j.jns.2016.02.004

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abstract = "Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.",

keywords = "Alzheimer's disease, Frontotemporal dementia, Methylation, Neurodegeneration, Peripheral marker, Pin1",

author = "Evelyn Ferri and Beatrice Arosio and Claudio D'Addario and Daniela Galimberti and Cristina Gussago and Mariangela Pucci and Martina Casati and Chiara Fenoglio and Carlo Abbate and Rossi, {Paolo Dionigi} and Scarpini, {Elio Angelo} and Mauro Maccarrone and Daniela Mari",

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doi = "10.1016/j.jns.2016.02.004",

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AU - Ferri, Evelyn

AU - Arosio, Beatrice

AU - D'Addario, Claudio

AU - Galimberti, Daniela

AU - Gussago, Cristina

AU - Pucci, Mariangela

AU - Casati, Martina

AU - Fenoglio, Chiara

AU - Abbate, Carlo

AU - Rossi, Paolo Dionigi

AU - Scarpini, Elio Angelo

AU - Maccarrone, Mauro

AU - Mari, Daniela

PY - 2016/3/15

Y1 - 2016/3/15

N2 - Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.

AB - Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.

KW - Alzheimer's disease

KW - Frontotemporal dementia

KW - Methylation

KW - Neurodegeneration

KW - Peripheral marker

KW - Pin1

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JF - Journal of the Neurological Sciences

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Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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