Abstract
Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
| Original language | English |
|---|---|
| Pages (from-to) | 283-286 |
| Number of pages | 4 |
| Journal | Journal of the Neurological Sciences |
| Volume | 362 |
| DOIs | |
| Publication status | Published - Mar 15 2016 |
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Keywords
- Alzheimer's disease
- Frontotemporal dementia
- Methylation
- Neurodegeneration
- Peripheral marker
- Pin1
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease. / Ferri, Evelyn; Arosio, Beatrice; D'Addario, Claudio; Galimberti, Daniela; Gussago, Cristina; Pucci, Mariangela; Casati, Martina; Fenoglio, Chiara; Abbate, Carlo; Rossi, Paolo Dionigi; Scarpini, Elio Angelo; Maccarrone, Mauro; Mari, Daniela.
In: Journal of the Neurological Sciences, Vol. 362, 15.03.2016, p. 283-286.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease
AU - Ferri, Evelyn
AU - Arosio, Beatrice
AU - D'Addario, Claudio
AU - Galimberti, Daniela
AU - Gussago, Cristina
AU - Pucci, Mariangela
AU - Casati, Martina
AU - Fenoglio, Chiara
AU - Abbate, Carlo
AU - Rossi, Paolo Dionigi
AU - Scarpini, Elio Angelo
AU - Maccarrone, Mauro
AU - Mari, Daniela
PY - 2016/3/15
Y1 - 2016/3/15
N2 - Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
AB - Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
KW - Alzheimer's disease
KW - Frontotemporal dementia
KW - Methylation
KW - Neurodegeneration
KW - Peripheral marker
KW - Pin1
UR - http://www.scopus.com/inward/record.url?scp=84962308254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962308254&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2016.02.004
DO - 10.1016/j.jns.2016.02.004
M3 - Article
VL - 362
SP - 283
EP - 286
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
ER -