Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease

Evelyn Ferri, Beatrice Arosio, Claudio D'Addario, Daniela Galimberti, Cristina Gussago, Mariangela Pucci, Martina Casati, Chiara Fenoglio, Carlo Abbate, Paolo Dionigi Rossi, Elio Angelo Scarpini, Mauro Maccarrone, Daniela Mari

Research output: Contribution to journalArticlepeer-review

Abstract

Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalJournal of the Neurological Sciences
Volume362
DOIs
Publication statusPublished - Mar 15 2016

Keywords

  • Alzheimer's disease
  • Frontotemporal dementia
  • Methylation
  • Neurodegeneration
  • Peripheral marker
  • Pin1

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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