Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

T. Noda; H. Takaki; T. Kurita; K. Suyama; N. Nagaya; A. Taguchi; N. Aihara; S. Kamakura; K. Sunagawa; K. Nakamura; T. Ohe; M. Horie; C. Napolitano; J. A. Towbin; S. G. Priori; Wataru Shimizu

doi:10.1053/euhj.2001.3079

Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

T. Noda, H. Takaki, T. Kurita, K. Suyama, N. Nagaya, A. Taguchi, N. Aihara, S. Kamakura, K. Sunagawa, K. Nakamura, T. Ohe, M. Horie, C. Napolitano, J. A. Towbin, S. G. Priori, Wataru Shimizu

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome. Methods and Results: We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0·1 μg . kg^-1 of epinephrine followed by continuous infusion (0·1 μg · kg^-1 min^-1) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477±42 to 631± 59 ms; P

Original language	English
Pages (from-to)	975-983
Number of pages	9
Journal	European Heart Journal
Volume	23
Issue number	12
DOIs	https://doi.org/10.1053/euhj.2001.3079
Publication status	Published - Jun 2002

Keywords

Action potentials
Catecholamines
Genetics
Long-QT syndrome
Nervous system
Sympathetic

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Noda, T., Takaki, H., Kurita, T., Suyama, K., Nagaya, N., Taguchi, A., Aihara, N., Kamakura, S., Sunagawa, K., Nakamura, K., Ohe, T., Horie, M., Napolitano, C., Towbin, J. A., Priori, S. G., & Shimizu, W. (2002). Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. European Heart Journal, 23(12), 975-983. https://doi.org/10.1053/euhj.2001.3079

Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. / Noda, T.; Takaki, H.; Kurita, T.; Suyama, K.; Nagaya, N.; Taguchi, A.; Aihara, N.; Kamakura, S.; Sunagawa, K.; Nakamura, K.; Ohe, T.; Horie, M.; Napolitano, C.; Towbin, J. A.; Priori, S. G.; Shimizu, Wataru.

In: European Heart Journal, Vol. 23, No. 12, 06.2002, p. 975-983.

Research output: Contribution to journal › Article › peer-review

Noda, T, Takaki, H, Kurita, T, Suyama, K, Nagaya, N, Taguchi, A, Aihara, N, Kamakura, S, Sunagawa, K, Nakamura, K, Ohe, T, Horie, M, Napolitano, C, Towbin, JA, Priori, SG & Shimizu, W 2002, 'Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome', European Heart Journal, vol. 23, no. 12, pp. 975-983. https://doi.org/10.1053/euhj.2001.3079

Noda, T. ; Takaki, H. ; Kurita, T. ; Suyama, K. ; Nagaya, N. ; Taguchi, A. ; Aihara, N. ; Kamakura, S. ; Sunagawa, K. ; Nakamura, K. ; Ohe, T. ; Horie, M. ; Napolitano, C. ; Towbin, J. A. ; Priori, S. G. ; Shimizu, Wataru. / Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. In: European Heart Journal. 2002 ; Vol. 23, No. 12. pp. 975-983.

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abstract = "Aims: Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome. Methods and Results: We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0·1 μg . kg-1 of epinephrine followed by continuous infusion (0·1 μg · kg-1 min-1) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477±42 to 631± 59 ms; P",

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AU - Noda, T.

AU - Takaki, H.

AU - Kurita, T.

AU - Suyama, K.

AU - Nagaya, N.

AU - Taguchi, A.

AU - Aihara, N.

AU - Kamakura, S.

AU - Sunagawa, K.

AU - Nakamura, K.

AU - Ohe, T.

AU - Horie, M.

AU - Napolitano, C.

AU - Towbin, J. A.

AU - Priori, S. G.

AU - Shimizu, Wataru

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N2 - Aims: Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome. Methods and Results: We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0·1 μg . kg-1 of epinephrine followed by continuous infusion (0·1 μg · kg-1 min-1) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477±42 to 631± 59 ms; P

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